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Bioactive Actinomycetes: Reaching Rarity Through Sound Understanding of Selective Culture and Molecular Diversity
Book chapter   Peer reviewed

Bioactive Actinomycetes: Reaching Rarity Through Sound Understanding of Selective Culture and Molecular Diversity

D Ipek Kurtboke
Microbial Resources: From Functional Existence in Nature to Applications, pp.45-76
Academic Press
2017
url
https://doi.org/10.1016/B978-0-12-804765-1.00003-5View
Published Version

Abstract

actinobacteria actinomycetales actinomycetes functional diversity metagenomics rare species diversity selective isolation
The pioneering discoveries from actinomycetes not only ensured that they were prolific sources for biodiscoveries but also sparked global interest on these organisms. Labor intensive years resulted in the detection and isolation of many species of this group of bacteria but also created the libraries of these organisms which subsequently generated contemporary taxon-specific data. Molecular advances are now changing the scene to provide information on the diversity and functions of these organisms in natural ecosystems, but culturability is still an important aspect of biodiscovery to address to satisfy the needs of industry. These advances together with the application of highly specific isolation methods, generated via in-depth analysis of emerging molecular and metagenomic data, will provide a sound basis for culturability. This chapter will overview the past efforts, which resulted in the isolation of a significant number of genera and species belonging to actinomycetes, as well as describing the impact of current advances on the improved design of objective and target-directed selective isolation techniques enabling the isolation of new and industrially important species of the order. © 2017 Elsevier Inc. All rights reserved.

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