Abstract
Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia
Biological Psychiatry, Vol.81(10, Supplement), pp.S36-S37
Annual Scientific Convention and Meeting, 72nd (San Diego, United States, 18-May-2017–20-May-2017)
2017
Abstract
Background: Many studies report smaller hippocampal and amygdala volumes in PTSD, but findings are not always consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the PGC-ENIGMA PTSD Working Group. Methods: We analyzed neuroimaging and clinical data from 1,868 subjects contributed by 16 cohorts, representing the largest neuroimaging study of PTSD. We assessed the volumes of nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, lateral ventricle, and total intracranial volume (ICV). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results: The amygdala and hippocampus, after adjusting for age, sex, and ICV, were smaller in subjects with current PTSD (amygdala, D 5 20.11, p 5 0.025; hippocampus, D 5 20.17, p 5 0.00054). The ICV-unadjusted effect sizes for hippocampus and amygdala were larger (amygdala, D 5 20.16, p 5 0.0058; hippocampus, D 5 20.22, p 5 0.000048). Childhood trauma was associated with smaller amygdala volume (D 5 20.16, p 5 0.0044) and hippocampal volume (D 5 20.17, p 5 0.0031) in a model adjusting for age, sex, and ICV. The negative association with hippocampal volume in the female-only participants had a large effect size (D 5 20.31, p 5 0.00012). The other subcortical regions did not show significant PTSD or trauma effects. Whereas we hypothesized that both amygdala and hippocampus volume would differ in PTSD, the hippocampal result was significant after imposing a Bonferroni correction, which was not the case for the amygdala. Conclusions: Our study represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma without the biases faced by meta-analyses of previously published data.
Details
- Title
- Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia
- Authors
- Rajendra Morey (Author)Mark Logue (Author)Sanne van Rooij (Author)Emily Dennis (Author)Sarah Davis (Author)Jasmeet Hayes (Author)Jennifer Stevens (Author)Maria Densmore (Author)Saskia Koch (Author)Mayuresh Korgaonkar (Author)Lauren LeBois (Author)Matthew Peverill (Author)Neda Jahanshad (Author)Jim Lagopoulos (Author) - University of the Sunshine CoastElbert Gueze (Author)Tanja Jovanovic (Author)Chadi Abdallah (Author)Maxwell Bennett (Author)Anthony King (Author)John Krystal (Author)Richard Bryant (Author)Mark Miller (Author)Dick Veltman (Author)Katie McLaughlin (Author)Ruth Lanius (Author)Dan Stein (Author)Kathleen Thomaes (Author)Israel Liberzon (Author)Kerry Ressler (Author)Paul Thomson (Author)
- Publication details
- Biological Psychiatry, Vol.81(10, Supplement), pp.S36-S37
- Conference details
- Annual Scientific Convention and Meeting, 72nd (San Diego, United States, 18-May-2017–20-May-2017)
- Publisher
- Elsevier Inc.
- Date published
- 2017
- DOI
- 10.1016/j.biopsych.2017.02.099
- ISSN
- 0006-3223
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99451183902621
- Output Type
- Abstract
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