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The blood flow and fatigue response to isometric plantar-flexion exercise in patients with peripheral arterial disease
Abstract   Peer reviewed

The blood flow and fatigue response to isometric plantar-flexion exercise in patients with peripheral arterial disease

Brad Stefanovic, Fraser D Russell, P J Walker, S Green and Christopher D Askew
Journal of Science and Medicine in Sport, Vol.12(Supplement 1), pp.S56-S57
asics Conference of Science and Medicine in Sport, 2008 (Hamilton Island, Australia, 16-Oct-2008–18-Oct-2008)
2009
DOI: https://doi.org/10.1016/j.jsams.2008.12.132
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https://doi.org/10.1016/j.jsams.2008.12.132View
Published Version

Abstract

Human Movement and Sports Science peripheral arterial disease fatigue blood flow
Introduction: The aim of the present study was to assess the relationship between blood flow and fatigue during lower limb plantar-flexion exercise in peripheral arterial disease (PAD) and age matched control subjects. Methods: Subjects performed isometric plantar-flexion exercise tests. The protocol commenced with a series of maximum voluntary contractions (MVC) to determine muscle strength. This was followed by a continuous bout of intermittent submaximal exercise (12 contractions/min) to determine muscle endurance. MVCs were repeated throughout the endurance test to assess the rate of muscle fatigue. Blood flow measurements at rest, during cuff-induced reactive hyperaemia and exercise were measured via strain gauge plethysmography (SGP). Testing was conducted using both the most- and least-affected limbs of PAD subjects. Results: There was no difference in MVC force (strength) between PAD and control. Endurance of the PAD most-affected leg (484 ± 288.72 s) was less than that for the PAD least-affected leg (971.9 ± 403.95 s) and control legs (916 ± 373.94 s) (p < 0.05). The rate of fatigue throughout exercise tended to be greater (18–36%) in PAD compared with control. The reactive hyperaemic blood flow response was lower in the PAD most-affected leg (4.69 ± 2.26 ml/100 ml/min) compared with the least-affected leg (12.24 ± 9.91, p < 0.05) and control (32.44 ± 9.91, p < 0.001). Conclusion: These data confirm the negative affect of PAD on calf muscle endurance. This reduction in absolute muscle endurance is independent of muscle strength, and it is associated with a greater rate of fatigue during exercise. Alterations in blood flow kinetics, particularly at the onset of exercise, may contribute to the reduced muscle performance of PAD patients. [Presented at the asics Conference of science and medicine in sport 2008]

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