Subclinical Left Ventricular Dysfunction and Glycaemic Control Over Long-term Follow-up in Individuals with Type 2 Diabetes Mellitus: A Prospective Follow-up Study

D Holland; T Marwick; B Haluska; Kim Greaves; J Coombes; J Prins; Tony Stanton

doi:10.1016/j.hlc.2017.06.237

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Subclinical Left Ventricular Dysfunction and Glycaemic Control Over Long-term Follow-up in Individuals with Type 2 Diabetes Mellitus: A Prospective Follow-up Study

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Subclinical Left Ventricular Dysfunction and Glycaemic Control Over Long-term Follow-up in Individuals with Type 2 Diabetes Mellitus: A Prospective Follow-up Study

D Holland, T Marwick, B Haluska, Kim Greaves, J Coombes, J Prins and Tony Stanton

Heart, Lung and Circulation, Vol.26(Supplement 2), p.S148

Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 65th (Perth, Australia, 10-Aug-2017–13-Aug-2017)

2017

DOI: https://doi.org/10.1016/j.hlc.2017.06.237

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Abstract

Cardiovascular Medicine and Haematology

Public Health and Health Services

Background: Subclinical left ventricular dysfunction(LVD) is present in up to half of individuals with type 2 diabetes mellitus(T2DM) and is associated with adverse prognosis. The development of LVD and change in global longitudinal strain(GLS) over long-term follow-up in individuals with T2DM is unknown. Methods: 102 asymptomatic individuals (age 56±8yrs) with T2DM underwent clinical review, blood tests and resting echocardiography at baseline and after a follow-up over 9yrs. Participants were free of ischaemic/valvular heart disease, and had normal ejection fraction(>50%). GLS was used to identify LVD (GLS worse than -18.9%). Results: After 9.4±0.7 years(median), GLS decreased from -19.2±2.3% to -17.4±2.8% (p < 0.001) and there were more individuals with LVD (42% to 68%, p < 0.001). Those with poorer glycaemic control at follow-up (i.e. HbA1c≥7) had significant deterioration in GLS compared to those with optimal control (p = 0.039). Independent predictors of deteriorating GLS were age, weight, HbA1c and use of statins (p < 0.05 for all). Oral antidiabetic medications (including metformin) were protective (p < 0.001). Conclusion: Subclinical LVD is common in asymptomatic individuals with T2DM and progresses over long-term follow-up. Progression of LVD is associated with poor glycaemic control, advancing age, increases in body weight nd statin use, whereas diabetes therapy was protective. Therapeutic interventions in glycaemic control may prevent progression of LVD over long-term follow-up.

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Title: Subclinical Left Ventricular Dysfunction and Glycaemic Control Over Long-term Follow-up in Individuals with Type 2 Diabetes Mellitus: A Prospective Follow-up Study
Authors: D Holland (Author) - University of Queensland
T Marwick (Author) - Baker IDI Heart and Diabetes Institute
B Haluska (Author) - University of Queensland
Kim Greaves (Author) - Sunshine Coast Hospital and Health Service
J Coombes (Author) - University of Queensland
J Prins (Author) - University of Queensland
Tony Stanton (Author) - Sunshine Coast Hospital and Health Service
Publication details: Heart, Lung and Circulation, Vol.26(Supplement 2), p.S148
Conference details: Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 65th (Perth, Australia, 10-Aug-2017–13-Aug-2017)
Publisher: Elsevier Australia
Date published: 2017
DOI: 10.1016/j.hlc.2017.06.237
ISSN: 1443-9506
Organisation Unit: Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99451033802621
Output Type: Abstract

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