Small Abdominal Aortic Aneurysm is Associated With Endotoxin Tolerant-Like Macrophage Immunosuppression and Decreased Levels of the Resolution-Directed Mediator PGE2

Lara T Meital; Mark Windsor; Alesiya Maynard; K Schulze; R Magee; J O'Donnell; P Jha; Maria-Christina Perissiou; Steven Coverdale; J Golledge; Tom G Bailey; Christopher D Askew; Fraser D Russell

doi:10.1016/j.hlc.2018.06.681

Back

Small Abdominal Aortic Aneurysm is Associated With Endotoxin Tolerant-Like Macrophage Immunosuppression and Decreased Levels of the Resolution-Directed Mediator PGE2

Abstract

Peer reviewed

Small Abdominal Aortic Aneurysm is Associated With Endotoxin Tolerant-Like Macrophage Immunosuppression and Decreased Levels of the Resolution-Directed Mediator PGE2

Lara T Meital, Mark Windsor, Alesiya Maynard, K Schulze, R Magee, J O'Donnell, P Jha, Maria-Christina Perissiou, Steven Coverdale, J Golledge, …

Heart, Lung and Circulation, Vol.27(Supplement 2), p.S348

Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, 66th (Brisbane, Australia, 02-Aug-2018–05-Aug-2018)

2018

DOI: https://doi.org/10.1016/j.hlc.2018.06.681

Files and links (1)

url

https://doi.org/10.1016/j.hlc.2018.06.681View

Published Version

Abstract

Cardiovascular Medicine and Haematology

Public Health and Health Services

Background: Macrophages contribute to inflammatory processes occurring within the aortic wall of patients with abdominal aortic aneurysm (AAA). Macrophage function is modulated by endogenous regulatory mechanisms that include endotoxin tolerance, a phenomenon linked to aberrant Toll-like receptor 4 (TLR4) signalling. Since AAA is associated with the presence of known TLR4 activators, this study investigated the possibility that AAA macrophages exhibit an immunosuppressive phenotype reminiscent of tolerance.

Details

Title: Small Abdominal Aortic Aneurysm is Associated With Endotoxin Tolerant-Like Macrophage Immunosuppression and Decreased Levels of the Resolution-Directed Mediator PGE2
Authors: Lara T Meital (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Mark Windsor (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Alesiya Maynard (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
K Schulze (Author) - Sunshine Vascular
R Magee (Author) - Sunshine Coast University Hospital
J O'Donnell (Author) - Sunshine Coast University Hospital
P Jha (Author) - Sunshine Coast University Hospital
Maria-Christina Perissiou (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Steven Coverdale (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
J Golledge (Author) - James Cook University
Tom G Bailey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Christopher D Askew (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Fraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Heart, Lung and Circulation, Vol.27(Supplement 2), p.S348
Conference details: Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, 66th (Brisbane, Australia, 02-Aug-2018–05-Aug-2018)
Publisher: Elsevier Australia
Date published: 2018
DOI: 10.1016/j.hlc.2018.06.681
ISSN: 1443-9506; 1443-9506
Organisation Unit: School of Health - Biomedicine; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451471302621
Output Type: Abstract

Metrics

390 Record Views