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Prevalence of hepatotropic viruses HBV+HCV+HDV in HIV infected clients from Northern Nigeria
Abstract

Prevalence of hepatotropic viruses HBV+HCV+HDV in HIV infected clients from Northern Nigeria

Ameh S James, G Imade, U Placcid, S Illaya, G Abba, S Yohanna, M Obed, U Tanko and A Julius
Proceedings of the 5th International AIDS Society Conference
International AIDS Society (IAS) Conference: HIV Pathogenesis and Treatment and Prevention, 5th (Cape Town, South Africa, 19-Jul-2009–22-Jul-2009)
2009
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Abstract

Medical Microbiology Clinical Sciences HIV infected clients Nigeria hepatotropic viruses
Background: Because of shared routes of transmission,chronic HBV and HCV infections frequently complicate HIV disease.Chronic hepatitis caused by HBV or HCV can significantly affects the morbidity of HIV infected clients and influence the antiretroviral therapy (ART). The aim of the study was to assess the prevalence of HBV and HCV among HIV infected subjects before the initiation of ART. Methods: Retrospective hepatitis Laboratory diagnosis was performed on stored serum samples of 200 HIV+ clients before ART and 200 HIV- blood donors (controls). All the clients and controls were screened for hepatitis B Virus (HBV) and hepatitis C Virus (HCV) and confirmed with ELISA technique. HBV+ samples were tested for hepatitis D Virus (HDV). Route of infection was 100% heterosexual. EPI info 3.3.2 was used for results analysis. Results: HBV was observed in 38 clients: 13 males 34% (Range: 20%-51%) vs 25 females 66% (Range: 49%-80%) at 95% CI as against the 6 controls: 6 males 100% (Range: 0%-54%) vs females 0% (Range: 0%-46%) at 95% CI.HCV infection was observed in 19 clients: 3 males 16% (Range: 3%-40%) vs 16 females 84% (Range: 60%-97%) at 95 CI as against 2 controls: 2 males 100 % (Range: 0%-16%) vs females 0% (Range: 0%-84%) at 95% CI.HBV+ HDV clients were 6: 2 males 33 %( Range: 4%-78%) vs 4 females 67 %( Range: 22%-96%).HBV+HCV was observed in 4 female clients: 21% (Range: 6%-46%) while HBV+HCV+HDV in 1female client: 100% (Range: 0%-3%) at 95% CI. Mean CD4+ cells in HBV+ was 149/ul (p-value=0.05) vs 565/ul (p-value=0.96) in controls.While, mean CD4+ cells in HCV was 206/ul (p-value=0.88) vs 501/ul (p-value=0.96) in controls. Conclusions: This calls for hepatitis screening test as a routine in resource limited setting. HIV coinfection accelerates the natural course of HBV and of HCV. Therefore, the need for effective treatment strategies for these special difficult -to-treat client groups.

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