O6. Oral Ketamine and Zinc Supplementation Trial for Anorexia Nervosa

Rosiel Elwyn; Jules Mitchell; Adem Can; Megan Dutton; Jim Lagopoulos; Daniel Hermens

doi:10.1186/s40337-024-00993-2

Back

O6. Oral Ketamine and Zinc Supplementation Trial for Anorexia Nervosa

Abstract

Open access

Peer reviewed

O6. Oral Ketamine and Zinc Supplementation Trial for Anorexia Nervosa

Rosiel Elwyn, Jules Mitchell, Adem Can, Megan Dutton, Jim Lagopoulos and Daniel Hermens

Journal of Eating Disorders, Vol.12(S1), pp.2-3

Australia & New Zealand Academy for Eating Disorders (ANZAED) Annual Conference, 20th (Sydney, Australia, 11-Aug-2022–13-Aug-2022)

2024

DOI: https://doi.org/10.1186/s40337-024-00993-2

Files and links (1)

pdf

s40337-024-00993-2766.37 kBDownload View

Published VersionCC BY V4.0, Open Access

Abstract

This study is an open-label, dose-ranging clinical trial aiming to explore the safety, feasibility and tolerability of a sub-anaesthetic dose of oral ketamine and combined zinc supplementation for individuals with low and higher weight anorexia nervous (AN and ‘atypical’ AN) of all gender identities aged 18-30 years. Participants will undergo 6 weeks of a combined novel psycho-pharmaceutical treatment, with continual supplementation for the remainder 6 weeks of the trial to support neuroplastic brain changes (synaptic remodelling). Medical, mental health and cognitive assessments and brain imaging will occur at study entry and at two additional time points. Gut microbiome fecal sampling collection will occur at study entry and at 6 weeks of the combined treatment. The primary objective is to determine the safety, feasibility and tolerability of the novel psycho-pharmaceutical treatment in young participants diagnosed with early onset, chronic AN. Additionally, it aims to determine the influence of the treatment on low and higher weight AN in psychological, cognitive and behavioural domains, on interoceptive function and on the gut microbiome. Exploratory objectives include gut microbial profiles, neuroimaging and blood biomarker correlates associated with and/or predictive of treatment response.

Details

Title: O6. Oral Ketamine and Zinc Supplementation Trial for Anorexia Nervosa
Authors: Rosiel Elwyn (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jules Mitchell - University of the Sunshine Coast, Queensland, Thompson Institute
Adem Can - University of the Sunshine Coast, Queensland, Thompson Institute
Megan Dutton - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos - University of the Sunshine Coast, Queensland, Thompson Institute
Daniel Hermens - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Journal of Eating Disorders, Vol.12(S1), pp.2-3
Conference details: Australia & New Zealand Academy for Eating Disorders (ANZAED) Annual Conference, 20th (Sydney, Australia, 11-Aug-2022–13-Aug-2022)
Publisher: BioMed Central Ltd.
Date published: 2024
DOI: 10.1186/s40337-024-00993-2
ISSN: 2050-2974
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Organisation Unit: School of Health - Biomedicine; Thompson Institute; School of Law and Society
Language: English
Record Identifier: 991014998602621
Output Type: Abstract

Metrics

100 File views/ downloads

123 Record Views

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Nutrition & Dietetics; Psychiatry; Psychology, Clinical