Abstract
Moderate/severe traumatic brain injury accelerates normal brain aging
Journal of Neurotrauma, Vol.39(11-12), pp.A-50-A-50
Annual Symposium of the National Neurotrauma Society - Evolution of neutrotrauma research past present and future, 39th (Atlanta, United States, 26-Jun-2022 - 29-Jun-2022)
2022
Abstract
Traumatic brain injury (TBI) can have lifelong consequences for brain health, but exactly how injury influences the normal aging processes is unclear. We leverage data from five cohorts participating in the ENIGMA Adult Mod/Sev TBI working group, some of which are multi‐site projects. A total of 651 participants (405 TBI/246 comparison, 499 M/152 F, age 49.7 ± 18.4 years,age range 17‐85 years) were included. Participants with TBI were scanned with a mean post‐injury interval of 16.1 ± 18.2 years (range = 2 months‐66 years). Brain age was estimated using BrainAgeR (https://github.com/james-cole/brainageR). Participant T1‐weighted MRI data was processed and compared to the original training dataset (N = 3,377 from 7 MRI datasets, age range = 18‐100 years) and brain age was predicted using the kernlab package in R. Tissue segmentations were visually checked for quality. Predicted age was subtracted from chronological age to generate a brain age gap (BAG) so that negative scores indicated younger‐appearing brains. Group differences in BAG were estimated using a linear mixed effects model, with nested random effects to control for cohort and multiple sites within cohorts, covarying for chronological age. The TBI group had a significantly older brain age (β = 3.3 years older, p = 6.0x10‐5). Critically, there was a significant group by age interaction, with older predicted brain ages in older TBI patients, suggesting that not only does atrophy occur after aging (a well‐documented phenomenon) but with age the slope of atrophy is steeper.
Details
- Title
- Moderate/severe traumatic brain injury accelerates normal brain aging
- Authors
- Emily Dennis (Author) - University of UtahAlexander Olsen (Author) - Norwegian University of Science and TechnologyMaheen Adamson (Author) - VA Palo Alto Health Care SystemHoushang Amiri (Author) - Kerman University of Medical SciencesErin Bigler (Author) - University of UtahKaren Caeyenberghs (Author) - Deakin UniversityKristen Dams-O'Connor (Author) - Icahn School of Medicine at Mount SinaiEvelyn Deutscher (Author) - Deakin UniversityEkaterina Dobryakova (Author) - Kessler FoundationHelen Genova (Author) - Kessler FoundationJordan Grafman (Author) - Shirley Ryan AbilityLab (Chicago, United States) - sralabAsta Håberg (Author) - Norwegian University of Science and TechnologyCooper Hodges (Author) - University of UtahAndrei Irimia (Author) - University of Southern CaliforniaNeda Jahanshad (Author) - University of Southern CaliforniaRuchira Jha (Author) - University of PittsburghHannah Lindsey (Author) - University of UtahAbdalla Mohamed (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMartin Monti (Author) - University of California Los AngelesMary Newsome (Author) - Baylor College of MedicineGershon Spitz (Author) - Monash UniversityPaul M Thompson (Author) - University of Southern CaliforniaDavid Tate (Author) - University of UtahElisabeth A Wilde (Author) - University of UtahFrank Hillary (Author) - Penn State Abington
- Publication details
- Journal of Neurotrauma, Vol.39(11-12), pp.A-50-A-50
- Conference details
- Annual Symposium of the National Neurotrauma Society - Evolution of neutrotrauma research past present and future, 39th (Atlanta, United States, 26-Jun-2022 - 29-Jun-2022)
- Publisher
- Mary Ann Liebert, Inc. Publishers
- DOI
- 10.1089/neu.2022.29126.abstracts
- ISSN
- 1557-9042
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99668498002621
- Output Type
- Abstract