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Long-term endurance training effects on CD4+ Lymphocyte Activation in Young and Old Men
Abstract   Peer reviewed

Long-term endurance training effects on CD4+ Lymphocyte Activation in Young and Old Men

Suzanne Broadbent
Medicine and Science in Sports and Exercise, Vol.43(5, Supplement 1), p.338
American College of Sports Medicine (ACSM) Annual Conference, 58th (Denver, United States, 31-May-2011–04-Jun-2011)
2011
DOI: https://doi.org/10.1249/01.MSS.0000400932.36840.c2
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https://doi.org/10.1249/01.MSS.0000400932.36840.c2View
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Abstract

Human Movement and Sports Science Public Health and Health Services lymphocyte activation endurance training males
Regular exercise is thought to maintain or improve the adaptive immune (lymphocyte) response but there is little data on the long-term exercise effects on CD4+ activation in young and older individuals. PURPOSE: To investigate if 12 months of aerobic/endurance training would enhance CD4+ activation via increased CD25 receptor expression and density in trained older and young men compared to sedentary controls. METHODS: We compared young (30±5 yr) trained (TRY, n = 14) and sedentary (UTY, n = 12) men to older (69±5 yr) trained (TRO, n = 14) and sedentary (UTO, n = 10) men for 12 months. Older men cycled for three 50 min sessions per week (60-70% VO2peak) while the TRY group completed daily endurance training (90-120 min per day, 60-80% VO2peak). Venous blood was analysed every month for resting lymphocyte count and CD4+CD25+ expression and density by flow cytometry. Results were analysed by repeated measures two-way ANOVA (time vs group) with Bonferroni post hoc test (between-group and between-month), with p<0.05. RESULTS: The TRY group had a significantly higher concentration of CD4+ than the UTY for 4 months (37±7%); there was no difference in lymphocyte count between TRO and UTO. The TRO group had a significantly greater percentage of CD4+CD25+ than the UTO group (39±16%) for 8 months, and TRY (52±20%) and UTY (57±19%) groups for 6 months. The TRO, TRY and UTY groups showed a significantly different % of CD4+CD25+ compared to the previous month in April, May, October and November. CD25 density was significantly greater in the TRY compared to UTY group (34±11%) for 10 months, and in TRY compared to TRO (39±13%) and UTO (44±12%) groups for 10 months. CD25 density was significantly different to the previous month for TRY and UTY in April, May, July, August, September, October; for TRO and UTO, in February, September. CONCLUSION: Moderate intensity/duration endurance training increased the percentage of CD4+ expressing CD25+ in older men, possibly by increasing memory cells. Endurance training in young athletes increased CD4+CD25+ density rather than the number/percentage of lymphocytes positive for the receptor. Exercise may increase the CD4+ response through different mechanisms depending upon age. Furthermore, there are seasonal differences in CD4+CD25+ expression which may affect adaptive immunity.

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