Human memory CD4+T Cells Maintained in the Absence of Antigen Developed Regulatory T Cells Capable of Suppressing Antibody Responses

Adam McKinlay; K J Radford; D Gardiner; D Khalil; K Field; Fiona Burnell; D N J Hart; S Vuckovic

doi:10.1111/j.1399-0039.2005.00523.x

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Human memory CD4+T Cells Maintained in the Absence of Antigen Developed Regulatory T Cells Capable of Suppressing Antibody Responses

Abstract

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Human memory CD4+T Cells Maintained in the Absence of Antigen Developed Regulatory T Cells Capable of Suppressing Antibody Responses

Adam McKinlay, K J Radford, D Gardiner, D Khalil, K Field, Fiona Burnell, D N J Hart and S Vuckovic

Tissue Antigens, Vol.66(5), pp.581-582

Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, 35th (Melbourne, Australia, 04-Dec-2005–08-Dec-2005)

2005

DOI: https://doi.org/10.1111/j.1399-0039.2005.00523.x

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Abstract

Biochemistry and Cell Biology

human memory

CD4+T cells

Cytokines and antigen presenting cells (APC) maintain the mature T cell repertoire by homeostatic proliferation in the periphery. There are no conclusive data on the number and function of human memory CD4+T cells maintained in the periphery, in the absence of antigen, as a result of exposure to cytokines and access to blood APC. We showed that exposure to cytokines IL-7 and IL-15 and access to the MHC class II molecules on blood myeloid dendritic cells (MDC) allowed proliferation of memory CD4+T cells, which display a broad usage of the TCR V b repertoire. Memory CD4+T cells developed the capacity to suppress PWM-driven IgG and IgM antibody responses after exposure to IL-7 and IL-15 and independent of the access to blood MDC or Mo. The suppression of antibody responses by these memory CD4+T cells is dose-dependent: low numbers enhanced, whereas high numbers suppressed antibody responses. We conclude that IL-7, IL-15 and blood APC contribute to immunity by facilitating differentiation of regulatory memory CD4+T cells, which are capable of suppressing B cell differentiation and antibody production, as well as their role in controlling the number and effector function of memory CD4+T cells.

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Title: Human memory CD4+T Cells Maintained in the Absence of Antigen Developed Regulatory T Cells Capable of Suppressing Antibody Responses
Authors: Adam McKinlay (Author) - Mater Medical Research Institute
K J Radford (Author) - Mater Medical Research Institute
D Gardiner (Author) - Mater Medical Research Institute
D Khalil (Author) - Mater Medical Research Institute
K Field (Author) - University of Melbourne
Fiona Burnell (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
D N J Hart (Author) - Mater Medical Research Institute
S Vuckovic (Author) - Mater Medical Research Institute
Publication details: Tissue Antigens, Vol.66(5), pp.581-582
Conference details: Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, 35th (Melbourne, Australia, 04-Dec-2005–08-Dec-2005)
Publisher: Blackwell Munksgaard
Date published: 2005
DOI: 10.1111/j.1399-0039.2005.00523.x
ISSN: 0001-2815
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449850802621
Output Type: Abstract

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