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Effects of a clinical referral and exercise program for men who have completed active treatment for prostate cancer: a multicentre cluster randomized controlled trial (ENGAGE)
Abstract   Peer reviewed

Effects of a clinical referral and exercise program for men who have completed active treatment for prostate cancer: a multicentre cluster randomized controlled trial (ENGAGE)

Patricia M Livingston, Melinda Craike, Jo Salmon, Kerry Courneya, Cadeyrn J Gaskin, Steve F Fraser, Mohammadreza Mohebbi, Suzanne Broadbent, Mari Botti, Bridie Kent, …
Asia-Pacific Journal of Clinical Oncology, Vol.10, p.162
World Cancer Congress, 2014 (Melbourne, Australia, 03-Dec-2014–06-Dec-2014)
2014
DOI: https://doi.org/10.1111/ajco.12332
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https://doi.org/10.1111/ajco.12332View
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Abstract

Oncology and Carcinogenesis
Background: Exercise programs have a positive impact on quality of lifeoutcomes in men with prostate cancer and have been shown to be safe,feasible and effective. Despite the potential benefits, many men living withprostate cancer do not participate in regular exercise.Aim: To test the efficacy of a clinician referral and exercise program toimprove physical activity levels, psychological wellbeing and quality of lifeamong men with prostate cancer.Methods: A multicentre, cluster randomized controlled trial in Melbourne,Australia, randomized 15 clinicians to either refer eligible participants(n = 54) to a supervised exercise program (two gym sessions and one home-based session per week for 12 weeks) or follow usual care (n = 93). Theprimary outcome was self-reported physical activity. Secondary outcomes:an objective measure of physical activity, quality of life, levels of anxiety andsymptoms of depression.Results: At 12 weeks, no significant intervention effects were observed forcombined moderate and vigorous physical activity levels (effect size: 0.08;95% CI: -0.28, 0.45; p = 0.48); significant intervention effects were observedfor vigorous-intensity exercise (effect size: 0.46; 95% CI: 0.09, 0.82;p = 0.010). Significant intervention effects were observed for the percentageof participants meeting exercise guidelines (≥150 minutes per week) basedon combined moderate-vigorous (Odds Ratio (OR): 3.9; 95% CI: 1.9, 7.8;p = 0.002) exercise; a significant inverse effect was observed on anxietylevels (effect size: 0.42, 95% CI: 0.06, 0.79; p = 0.02) and borderline inter-vention effects for depression symptoms (effect size: -0.35, 95% CI: -0.71,0.02; p = 0.06); 80% of participants reported the clinician's recommenda-tion influenced them to participate in the 12-week exercise program.Conclusions: Clinicians are ideally suited to refer men to tailored exerciseprograms as part of their clinical care for men who have completed activetreatment for prostate cancer, to improve physical activity levels and qualityof life outcomes.

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