Abstract
Contrast-Enhanced Ultrasound Measures of Skeletal Muscle Post-Occlusive Hyperaemia: What is the Effect of Occlusion Duration?
Heart, Lung and Circulation, Vol.29(Supplement 2), pp.S362-S362
Cardiac Society of Australia and New Zealand Annual Scientific Meeting, 68th (Virtual, 11-Dec-2020–13-Dec-2020)
2020
Abstract
Background:
Impaired skeletal muscle post-occlusive reactive hyperaemia is demonstrated in cardiovascular disease (CVD); however, studies report poor reliability. The use of different stimuli [1-minute (min) or 5-min occlusion] may contribute to measurement variance. We aimed to compare the effect of occlusion duration on contrast-enhanced ultrasound (CEU) measures of skeletal muscle microvascular blood flow in healthy older adults (n=15, 67±11 years).
Methods:
Microvascular blood flow (=microvascular volume x microvascular velocity) of the medial gastrocnemius muscle was measured in duplicate (≥48h apart) following a 1-min, 3-min, and 5-min thigh cuff occlusion (200mmHg) using real-time destruction-replenishment CEU. Occlusion test order was randomised at visit 1 and performed in the same order at both visits.
Results:
Mean microvascular blood flow was higher after 3-min (3.71±1.46 aU/s) and 5-min (3.47±1.48 aU/s) compared with 1-min (2.42±1.27 aU/S, p=0.002) which corresponded with higher microvascular volume after 3-min (22.74±9.91 aU) and 5-min (24.67±11.97 aU) compared with 1-min (14.25±11.46 aU, p=<0.001). There was no difference in microvascular velocity between the conditions. Test-retest reliability was higher for flow after 5-min [Intraclass correlation coefficient (ICC) 0.49] compared with 1-min (ICC 0.34) and 3-min (ICC 0.35).
Conclusion:
This study highlights that a 5-min occlusion results in a greater and more reliable measure of skeletal muscle microvascular blood flow compared with 1-min in healthy older adults. A 5-min occlusion may therefore result in more representative and sensitive measures of impaired skeletal muscle post-occlusive reactive hyperaemia in CVD populations.
Details
- Title
- Contrast-Enhanced Ultrasound Measures of Skeletal Muscle Post-Occlusive Hyperaemia: What is the Effect of Occlusion Duration?
- Authors
- Grace Young (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyKim Greaves (Author) - Sunshine Coast University HospitalDavid Chang (Author) - Sunshine Coast University HospitalJ Hwan Lam (Author) - Sunshine Coast University HospitalDigby Krastins (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyYuri Kriel (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyFraser Russell (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyTony Stanton (Author) - Sunshine Coast University HospitalChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
- Publication details
- Heart, Lung and Circulation, Vol.29(Supplement 2), pp.S362-S362
- Conference details
- Cardiac Society of Australia and New Zealand Annual Scientific Meeting, 68th (Virtual, 11-Dec-2020–13-Dec-2020)
- Publisher
- Elsevier Australia
- Date published
- 2020
- DOI
- 10.1016/j.hlc.2020.09.731
- ISSN
- 1444-2892
- Organisation Unit
- School of Health - Sports & Exercise Science; Centre for Human Factors and Sociotechnical Systems; School of Health - Biomedicine; Centre for Bioinnovation; Faculty of Science, Health, Education and Engineering; School of Health and Behavioural Sciences - Legacy; School of Nursing, Midwifery and Paramedicine - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster
- Language
- English
- Record Identifier
- 99488505502621
- Output Type
- Abstract
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