Analysis of FMRI bold activation during the tower of London task using cortical pattern matching

P E Rasser; P Johnston; Jim Lagopoulos; P B Ward; U Schall; R Thienel; S Bender; P M Thompson

doi:10.1016/S0920-9964(03)81221-5

Back

Analysis of FMRI bold activation during the tower of London task using cortical pattern matching

Abstract

Peer reviewed

Analysis of FMRI bold activation during the tower of London task using cortical pattern matching

P E Rasser, P Johnston, Jim Lagopoulos, P B Ward, U Schall, R Thienel, S Bender and P M Thompson

Schizophrenia Research, Vol.60(1, Supplement), p.232

IXth International Congress on Schizophrenia Research (Colorado Springs, United States, 29-Mar-2003–02-Apr-2003)

2003

DOI: https://doi.org/10.1016/S0920-9964(03)81221-5

Files and links (1)

url

https://doi.org/10.1016/S0920-9964(03)81221-5View

Published Version

Abstract

Medical and Health Sciences

Psychology and Cognitive Sciences

schizophrenia

fMRI

We tested the hypothesis that novel cortical surface modeling approaches can permit more accurate localisation of functional deficits in schizophrenia, and more sharply defined activation foci. We created two average models of cerebral cortex from 3D structural magnetic resonance images (sMRI) of ten first-episode male patients with schizophrenia and ten age- and sex- matched controls. 3D functional magnetic resonance imaging (fMRI) BOLD activation data, obtained while subjects performed the 'Tower of London' task, was then mapped to both cortex models for comparison across diagnostic groups (patient and control) and between cortical alignment methods. The first average cortical model of cortex was created by identifying 17 salci on each hemisphere of each subject's brain. These sulci were geometrically averaged, and each subject's cortex warped into alignment with the average sulci. The second average cortical model of cortex was developed by aligning individual sMRIs to a template, intensity averaging, and extracting the cortex from the resulting average image, fMRI data showed increased activation with task difficulty in the control group in the left Brodmann's areas 44, 7, 37, and 18 and in the fight Brodmann's area 7. In the patient group, increased activation with task difficulty was seen in the left Brodmann's area 10 and in the right Brodmann's area 18. Significantly decreased activation with task difficulty was found in the left and fight Brodmann's area 9 of the patient group; this was not observed in the control group. Sulcal averaging and cortical data warping resulted in sharper localisation of the functional data when compared to the functional data mapped to the cortical model derived from an average intensity brain. Future comparisons will relate these functional differences to differences in cortical grey matter density in patients and controls.

Details

Title: Analysis of FMRI bold activation during the tower of London task using cortical pattern matching
Authors: P E Rasser (Author) - NISAD
P Johnston (Author) - NISAD
Jim Lagopoulos (Author) - NISAD
P B Ward (Author) - NISAD
U Schall (Author) - NISAD
R Thienel (Author) - NISAD
S Bender (Author) - NISAD
P M Thompson (Author) - NISAD
Publication details: Schizophrenia Research, Vol.60(1, Supplement), p.232
Conference details: IXth International Congress on Schizophrenia Research (Colorado Springs, United States, 29-Mar-2003–02-Apr-2003)
Publisher: Elsevier BV
Date published: 2003
DOI: 10.1016/S0920-9964(03)81221-5
ISSN: 0920-9964
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450475102621
Output Type: Abstract

Metrics

515 Record Views

1 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites