Genomic instability in obesity-associated colon cancer

Jiezhong Chen; Ming-Tat Ling; Renfu Shao

doi:10.3978/j.issn.2224-4778.2013.10.06

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Genomic instability in obesity-associated colon cancer

Journal article

Peer reviewed

Genomic instability in obesity-associated colon cancer

Jiezhong Chen, Ming-Tat Ling and Renfu Shao

Translocational Gastrointestinal Cancer, Vol.3(2), pp.90-97

2014

DOI: https://doi.org/10.3978/j.issn.2224-4778.2013.10.06

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Abstract

Genetics

DNA repair

cell cycle

phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)

mitogen activated protein kinases (MAPK)

telomere

Epidemiological studies have demonstrated the association between obesity and colon cancer. Many studies using animal models have also confirmed that obesity increases colon cancer incidence. Multiple cancer risk factors in obesity have been identified, which can activate multiple signalling pathways to promote cell proliferation and decrease apoptosis. The mechanisms for obesity-associated colon cancer, however, are not fully elucidated. In this review, the possible roles of genomic instability in obesity-associated colon cancer are summarized. It is known that genomic instability is critical for the carcinogenesis of colon cancer. Recent studies have provided convincing evidence that obesity can increase genomic instability. Therefore, it is highly possible that genomic instability has an important role in obesity-associated colon cancer. Particularly, the activation of phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and mitogen activated protein kinases (MAPK) signalling pathways in obesity may mediate genomic instability in obesityassociated colon cancer.

Details

Title: Genomic instability in obesity-associated colon cancer
Authors: Jiezhong Chen (Author) - University of Queensland
Ming-Tat Ling (Author) - Queensland University of Technology
Renfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Translocational Gastrointestinal Cancer, Vol.3(2), pp.90-97
Publisher: AME Publishing Company
Date published: 2014
DOI: 10.3978/j.issn.2224-4778.2013.10.06
ISSN: 2224-476X; 2224-476X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449004502621
Output Type: Journal article

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