In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand

Ngoc Minh Hien Phan; Helen M Faddy; Robert Flower; Kirsten Spann; Eileen Roulis

doi:10.3390/v12040427

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In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand

Journal article

Open access

Peer reviewed

In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand

Ngoc Minh Hien Phan, Helen M Faddy, Robert Flower, Kirsten Spann and Eileen Roulis

Viruses, Vol.12(4), 427

2020

DOI: https://doi.org/10.3390/v12040427

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Abstract

genetic diversity

genotypes

HbsAg subtypes

human hepatitis B virus

mutations

recombination

serotypes

The extent of whole genome diversity amongst hepatitis B virus (HBV) genotypes is not well described. This study aimed to update the current distribution of HBV types and to investigate mutation rates and nucleotide diversity between genotypes in Southeast Asia, Australia and New Zealand. We retrieved 930 human HBV complete genomes from these regions from the NCBI nucleotide database for genotyping, detection of potential recombination, serotype prediction, mutation identification and comparative genome analyses. Overall, HBV genotypes B (44.1%) and C (46.2%) together with predicted serotypes adr (36%), adw2 (29%) and ayw1 (19.9%) were the most commonly circulating HBV types in the studied region. The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types. The study also highlighted the distinct nucleotide diversity of HBV genotypes for whole genome and along the genome length. Therefore, this study provided a robust update to HBV currently circulating in Southeast Asia, Australia and New Zealand as well as an insight into the association of HBV genetic hypervariability and prevalence of well reported mutations.

Details

Title: In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand
Authors: Ngoc Minh Hien Phan (Author) - Queensland University of Technology
Helen M Faddy (Author) - University of the Sunshine Coast - School of Health and Sport Sciences
Robert Flower (Author) - Queensland University of Technology
Kirsten Spann (Author) - Queensland University of Technology
Eileen Roulis (Author) - Queensland University of Technology
Publication details: Viruses, Vol.12(4), 427
Publisher: MDPI AG
Date published: 2020
DOI: 10.3390/v12040427
ISSN: 1999-4915; 1999-4915
Copyright note: Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451333802621
Output Type: Journal article
Research Statement: false

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Collaboration types: Domestic collaboration
Web Of Science research areas: Virology

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