Journal article
Aerobic training increases the stimulated percentage of CD4+ CD25+ in older men but not older women
European Journal of Applied Physiology, Vol.103(1), pp.79-87
2008
Abstract
The purpose of the present study was to determine whether 12 months of moderate intensity cycling would increase the expression of IL-2 (CD25+) receptors in T helper (CD4+) lymphocytes in men and women aged 65-75 years. Fourteen men and 10 women completed 52 weeks of moderate intensity cycling (60% VO2peak). Subjects trained (TR) three times per week for 45 min per session. Eight age-matched untrained (UT) male and eight UT female subjects acted as controls. Resting blood samples were taken from TR and UT subjects every 4 weeks. Leukocyte concentration was measured using a full blood count. PHA-stimulated CD4+ lymphocytes were analysed for changes in the expression of CD25+, by flow cytometry. Training significantly increased VO2peak (l min-1, ml kg-1 min-1) in male (+14.3, +16%) and female (+16.7, +27.8%) groups. The TR male group showed a significantly lower percentage of CD4+CD25+ than the male UT in January but the TR male percentage was significantly higher than the UT male group during February, March, April, May, June, September B and December. The female TR group showed a significantly higher percentage CD4+CD25+ than the female UT only during July. There were also significant sequential monthly changes in the percentage of CD4+CD25+ for male and female UT and TR groups. Significant increases in the percentage of CD4+ CD25+ in the male TR group suggest training-enhanced lymphocyte mitogenic responsiveness. Moderate intensity long-term training may increase the recruitment of active memory CD4+ CD25+ in men rather than women. © Springer-Verlag 2008.
Details
- Title
- Aerobic training increases the stimulated percentage of CD4+ CD25+ in older men but not older women
- Authors
- Suzanne Broadbent (Author) - Massey University, New ZealandG Gass (Author) - Bond University
- Publication details
- European Journal of Applied Physiology, Vol.103(1), pp.79-87
- Publisher
- Springer
- DOI
- 10.1007/s00421-007-0664-8
- ISSN
- 1439-6319
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science
- Language
- English
- Record Identifier
- 99451284002621
- Output Type
- Journal article
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