Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic cinetobacter baumannii pneumonia

Ella M Meumann; Nicholas M Anstey; Bart J Currie; Kim A Piera; Robert Baird; Derek S Sarovich; Joshua S Davis

doi:10.1093/ofid/ofz263

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Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic cinetobacter baumannii pneumonia

Journal article

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Peer reviewed

Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic cinetobacter baumannii pneumonia

Ella M Meumann, Nicholas M Anstey, Bart J Currie, Kim A Piera, Robert Baird, Derek S Sarovich and Joshua S Davis

Open Forum Infectious Diseases, Vol.6(7), pp.1-4

2019

DOI: https://doi.org/10.1093/ofid/ofz263

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Abstract

acinetobacter baumannii

community-acquired pneumonia

recurrence

relapse

whole-genome sequencing

Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in three of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

Details

Title: Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic cinetobacter baumannii pneumonia
Authors: Ella M Meumann (Corresponding Author) - Royal Darwin Hospital
Nicholas M Anstey (Author) - Royal Darwin Hospital
Bart J Currie (Author) - Royal Darwin Hospital
Kim A Piera (Author) - Royal Darwin Hospital
Robert Baird (Author) - Royal Darwin Hospital
Derek S Sarovich (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Joshua S Davis (Author) - Royal Darwin Hospital
Publication details: Open Forum Infectious Diseases, Vol.6(7), pp.1-4
Publisher: Oxford University Press
Date published: 2019
DOI: 10.1093/ofid/ofz263
ISSN: 2328-8957; 2328-8957
Copyright note: Copyright © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99451114602621
Output Type: Journal article
Research Statement: false

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Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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