Journal article
A DNA Logic Gate Automaton for detection of Rabies and other Lyssaviruses
ChemPhysChem, Vol.18(13), pp.1735-1741
2017
Abstract
Immediate activation of biosensors is not always desirable, particularly if activation is due to non-specific interactions. Here we demonstrate the use of deoxyribozyme-based logic gate networks arranged into visual displays to precisely control activation of biosensors, and demonstrate a prototype molecular automaton able to discriminate between seven different genotypes of Lyssaviruses, including Rabies virus. The device uses novel mixed-base logic gates to enable detection of the large diversity of Lyssavirus sequence populations, while a NOT logic gate prevents non-specific activation across genotypes. The resultant device provides a user-friendly digital-like, but molecule-powered, dot-matrix text output for unequivocal results read-out that is highly relevant for point of care applications.
Details
- Title
- A DNA Logic Gate Automaton for detection of Rabies and other Lyssaviruses
- Authors
- Pavithra Vijayakumar (Author) - Columbia University, United StatesJoanne Macdonald (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- ChemPhysChem, Vol.18(13), pp.1735-1741
- Publisher
- Wiley - V C H Verlag GmbH & Co. KGaA
- Date published
- 2017
- DOI
- 10.1002/cphc.201700072
- ISSN
- 1439-7641; 1439-7641
- Copyright note
- Copyright © 2017. This is the accepted version of the following article: Vijayakumar, Pavithra; Macdonald, J (2017). A DNA Logic Gate Automaton for detection of Rabies and other Lyssaviruses. 18:13 1735-1741, which has been published in final form at http://dx.doi.org/10.1002/cphc.201700072
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451057202621
- Output Type
- Journal article
- Research Statement
- false
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