Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

Trong D Tran; Brice A P Wilson; Curtis J Henrich; Louis M Staudt; Lauren R H Krumpe; Emily A Smith; Jarrod B King; Karen L Wendt; Alberto M Stchigel; Andrew N Miller; Robert H Cichewicz; Barry R O'Keefe; Kirk R Gustafson

doi:10.1021/acs.jnatprod.8b00871

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Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

Journal article

Peer reviewed

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

Trong D Tran, Brice A P Wilson, Curtis J Henrich, Louis M Staudt, Lauren R H Krumpe, Emily A Smith, Jarrod B King, Karen L Wendt, Alberto M Stchigel, Andrew N Miller, …

Journal of Natural Products, Vol.82(1), pp.154-162

2019

DOI: https://doi.org/10.1021/acs.jnatprod.8b00871

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Abstract

Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7- 11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.

Details

Title: Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities
Authors: Trong D Tran (Author) - National Cancer Institute, United States
Brice A P Wilson (Author) - National Cancer Institute, United States
Curtis J Henrich (Author) - National Cancer Institute, United States
Louis M Staudt (Author) - National Cancer Institute, United States
Lauren R H Krumpe (Author) - National Cancer Institute, United States
Emily A Smith (Author) - National Cancer Institute, United States
Jarrod B King (Author) - University of Oklahoma, United States
Karen L Wendt (Author) - University of Oklahoma, United States
Alberto M Stchigel (Author) - Universitat Rovira i Virgili, Spain
Andrew N Miller (Author) - University of Illinois, United States
Robert H Cichewicz (Author) - University of Oklahoma, United States
Barry R O'Keefe (Author) - National Cancer Institute, United States
Kirk R Gustafson (Author) - National Cancer Institute, United States
Publication details: Journal of Natural Products, Vol.82(1), pp.154-162
Publisher: American Chemical Society
DOI: 10.1021/acs.jnatprod.8b00871
ISSN: 0163-3864
Organisation Unit: School of Science, Technology and Engineering; Centre for Bioinnovation; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450872502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy; Plant Sciences

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