Journal article
Genetic factors associated with iron storage in Australian blood donors
Blood Transfusion, Vol.16(2), pp.123-129
2018
Abstract
Background. Blood donors are at risk of developing iron deficiency and/or iron deficiency anaemia. This may affect their health and affect their eligibility to give subsequent donations. Investigating genetic factors that may predispose donors to high or low iron stores is of interest; this may assist with providing optimal management strategies for maintaining donor health. This study aimed to investigate whether the presence of selected single nucleotide polymorphisms (SNPs) affecting parameters of iron status were associated with ferritin levels in Australian donors. Material and methods. Samples (n=800) were collected from non-first-time blood donors in Queensland. Plasma ferritin levels were quantified and the genotypes for ten SNPs, identified by a review of relevant literature, were determined for each sample. Associations between SNPs and ferritin levels were investigated. Results. Three SNPs were associated with ferritin levels. In male donors, high ferritin levels were associated with the variant allele (G) of the SNP rs3923809 in the BTBD9 gene. An association with ferritin levels was also identified with the SNP rs235756 in the BMP2 gene in males. The SNP rs4820268 in the TMPRSS6 gene was associated with ferritin levels in females, with donors with the AG genotype being three times more likely to have low ferritin levels. Discussion. Variants in the genes TMPRSS, BTBD9 and BMP2 were associated with ferritin levels in Australian blood donors. These findings provide support that genetic testing may be useful for the generation of predictive algorithms that may allow for management strategies to be tailor-made for individual donors.
Details
- Title
- Genetic factors associated with iron storage in Australian blood donors
- Authors
- Y Ji (Author) - Australian Red Cross Blood ServiceR Flower (Author) - Australian Red Cross Blood ServiceC Hyland (Author) - Australian Red Cross Blood ServiceN Saiepour (Author) - University of QueenslandHelen M Faddy (Author) - University of Queensland
- Publication details
- Blood Transfusion, Vol.16(2), pp.123-129
- Publisher
- S I M T I Servizi srl
- DOI
- 10.2450/2016.0138-16
- ISSN
- 1723-2007
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99450828002621
- Output Type
- Journal article
Metrics
43 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Hematology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites