Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues

Michael J Sherratt; Clair Baldock; J Louise Haston; David F Holmes; Carolyn J P Jones; C Adrian Shuttleworth; Tim J Wess; Cay M Kielty

doi:10.1016/S0022-2836(03)00829-5

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Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues

Journal article

Peer reviewed

Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues

Michael J Sherratt, Clair Baldock, J Louise Haston, David F Holmes, Carolyn J P Jones, C Adrian Shuttleworth, Tim J Wess and Cay M Kielty

Journal of Molecular Biology, Vol.332(1), pp.183-193

2003

DOI: https://doi.org/10.1016/S0022-2836(03)00829-5

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Abstract

fibrillin microfibrils

molecular combing

Young's modulusatomic force microscopy

X-ray fibre diffraction

Fibrillin-rich microfibrils have endowed tissues with elasticity throughout multicellular evolution. We have used molecular combing techniques to determine Young's modulus for individual microfibrils and X-ray diffraction of zonular filaments of the eye to establish the linearity of microfibril periodic extension. Microfibril periodicity is not altered at physiological zonular tissue extensions and Young's modulus is between 78 MPa and 96 MPa, which is two orders of magnitude stiffer than elastin. We conclude that elasticity in microfibril-containing tissues arises primarily from reversible alterations in supra-microfibrillar arrangements rather than from intrinsic elastic properties of individual microfibrils which, instead, act as reinforcing fibres in fibrous composite tissues. © 2003 Elsevier Ltd. All rights reserved.

Details

Title: Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues
Authors: Michael J Sherratt (Author) - University of Manchester, United Kingdom
Clair Baldock (Author) - University of Manchester, United Kingdom
J Louise Haston (Author) - University of Stirling, United Kingdom
David F Holmes (Author) - University of Manchester, United Kingdom
Carolyn J P Jones (Author) - St Mary's Hospital, United Kingdom
C Adrian Shuttleworth (Author) - University of Manchester, United Kingdom
Tim J Wess (Author) - University of Stirling, United Kingdom
Cay M Kielty (Author) - University of Manchester, United Kingdom
Publication details: Journal of Molecular Biology, Vol.332(1), pp.183-193
Publisher: Academic Press
DOI: 10.1016/S0022-2836(03)00829-5
ISSN: 0022-2836
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Academic)
Language: English
Record Identifier: 99450668302621
Output Type: Journal article

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Web Of Science research areas: Biochemistry & Molecular Biology

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