Glycine and Glycine Receptor Signalling in Non-Neuronal Cells

J Van den Eynden; S Saheb Ali; N Horwood; S Carmans; B Brone; N Hellings; P Steels; Robert J Harvey; J M Rigo

doi:10.3389/neuro.02.009.2009

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Glycine and Glycine Receptor Signalling in Non-Neuronal Cells

Journal article

Open access

Peer reviewed

Glycine and Glycine Receptor Signalling in Non-Neuronal Cells

J Van den Eynden, S Saheb Ali, N Horwood, S Carmans, B Brone, N Hellings, P Steels, Robert J Harvey and J M Rigo

Frontiers in Molecular Neuroscience, Vol.2, pp.1-12

2009

DOI: https://doi.org/10.3389/neuro.02.009.2009

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Abstract

Neurosciences

glycine receptor

cytoprotection

glia

immune cells

renal cells

hepatocytes

endothelial cells

Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types. Modulatory effects were mainly described in immune cells, endothelial cells and macroglial cells, where glycine modulates proliferation, differentiation, migration and cytokine production. Activation of glycine receptors (GlyRs) causes membrane potential changes that in turn modulate calcium flux and downstream effects in these cells. Cytoprotective effects were mainly described in renal cells, hepatocytes and endothelial cells, where glycine protects cells from ischemic cell death. In these cell types, glycine has been suggested to stabilize porous defects that develop in the plasma membranes of ischemic cells, leading to leakage of macromolecules and subsequent cell death. Although there is some evidence linking these effects to the activation of GlyRs, they seem to operate in an entirely different mode from classical neuronal subtypes.

Details

Title: Glycine and Glycine Receptor Signalling in Non-Neuronal Cells
Authors: J Van den Eynden (Author) - Hasselt University, Belgium
S Saheb Ali (Author) - Hasselt University, Belgium
N Horwood (Author) - University College London, United Kingdom
S Carmans (Author) - Hasselt University, Belgium
B Brone (Author) - Hasselt University, Belgium
N Hellings (Author) - Hasselt University, Belgium
P Steels (Author) - Hasselt University, Belgium
Robert J Harvey (Author) - University College London, United Kingdom
J M Rigo (Author) - Hasselt University, Belgium
Publication details: Frontiers in Molecular Neuroscience, Vol.2, pp.1-12
Publisher: Frontiers Research Foundation
Date published: 2009
DOI: 10.3389/neuro.02.009.2009
ISSN: 1662-5099
Copyright note: Copyright © 2009 Van den Eynden, SahebAli, Horwood, Carmans, Brône, Hellings, Steels, Harvey and Rigo. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450549802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences

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