Correlation between susceptibility of infants to infections and interaction with Neutrophils Of Escherichia Coli strains causing neonatal and infantile Septicemia

L Ohman; K Tullus; Mohammad Katouli; L Burman; O Stendahl

doi:10.1093/infdis/171.1.128

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Correlation between susceptibility of infants to infections and interaction with Neutrophils Of Escherichia Coli strains causing neonatal and infantile Septicemia

Journal article

Peer reviewed

Correlation between susceptibility of infants to infections and interaction with Neutrophils Of Escherichia Coli strains causing neonatal and infantile Septicemia

L Ohman, K Tullus, Mohammad Katouli, L Burman and O Stendahl

Journal of Infectious Diseases, Vol.171(1), pp.128-133

1995

DOI: https://doi.org/10.1093/infdis/171.1.128

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Abstract

Clinical Sciences

Medical Microbiology

The ability of Escherichia coli strains causing invasive infections to associate to human neutrophils and induce oxygen radicals was studied in three groups of blood isolates from neonates and infants: low-virulence septicemia strains (LVS), normal septicemia strains (NS), and meningitis strains (M). Infants were classified by susceptibility to infection as low- (LR) or high-risk (HR). All LVS strains were isolated from HR infants and showed higher association to neutrophils (P less than .05) and induced a higher oxidative response (P less than .05) compared with that of NS and M strains from LR infants. Three LVS strains caused the cells to release oxidative metabolites extracellularly. Thus, impaired interaction with neutrophils is characteristic of virulent clones of E. coli capable of causing invasive infection in healthy full-term neonates. Furthermore, increased extracellular release of oxygen metabolites could harm the surrounding tissue and potentiate the inflammatory process.

Details

Title: Correlation between susceptibility of infants to infections and interaction with Neutrophils Of Escherichia Coli strains causing neonatal and infantile Septicemia
Authors: L Ohman (Author)
K Tullus (Author)
Mohammad Katouli (Author) - Karolinska Institute, Sweden
L Burman (Author)
O Stendahl (Author)
Publication details: Journal of Infectious Diseases, Vol.171(1), pp.128-133
Publisher: Oxford University Press
Date published: 1995
DOI: 10.1093/infdis/171.1.128
ISSN: 0022-1899
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450307902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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