Evidence for increased horizontal gene transfers among streptococci from group A streptococcal endemic regions

M R Davies; T N Tran; David J McMillan; K S Sriprakash

doi:10.1016/j.ics.2005.11.085

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Evidence for increased horizontal gene transfers among streptococci from group A streptococcal endemic regions

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Evidence for increased horizontal gene transfers among streptococci from group A streptococcal endemic regions

M R Davies, T N Tran, David J McMillan and K S Sriprakash

International Congress Series, Vol.1289, pp.188-192

Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005 - 29-Sep-2005)

Elsevier BV

2006

DOI: https://doi.org/10.1016/j.ics.2005.11.085

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Abstract

Other Medical and Health Sciences

streptococcus dysgalactiae

streptococcus pyogenes

horizontal gene transfer

group C streptococcus

streptococcal phage

Streptococcus dysgalactiae subsp. equisimilis (group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a similar spectrum of diseases as Streptococcus pyogenes (group A streptococcus, GAS). While the lateral acquisition of genes between these two phylogenetically closely related species is well documented, the extent and mechanisms of lateral transfers are yet to be elucidated. We have recently demonstrated that cross-species genetic transfers are common between GGS and two closely related human pathogens, group A streptococcus and the group B streptococcus. Furthermore, we suggested that phage mediated lateral gene transfers may occur more frequently in populations with a high burden of GAS infection. To further substantiate this, we examined the dissemination of a functional prophage in selected GGS and GAS isolates belonging to distinct genotypes from GAS-endemic and non-endemic regions. Our results confirm that phage mediated lateral transfers between GAS and GGS are common in GAS endemic regions. This observation further impacts on the epidemiology of GAS diseases in endemic regions and future vaccine stratagies

Details

Title: Evidence for increased horizontal gene transfers among streptococci from group A streptococcal endemic regions
Authors: M R Davies (Author) - Queensland Institute of Medical Research
T N Tran (Author) - Queensland Institute of Medical Research
David J McMillan (Author) - Queensland Institute of Medical Research
K S Sriprakash (Author) - Queensland Institute of Medical Research
Contributors: K S Sriprakash (Editor)
Publication details: International Congress Series, Vol.1289, pp.188-192
Conference details: Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005 - 29-Sep-2005)
Publisher: Elsevier BV
Date published: 2006
DOI: 10.1016/j.ics.2005.11.085
ISSN: 0531-5131
Organisation Unit: Centre for Bioinnovation; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450014302621
Output Type: Conference paper

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