Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder

Rico S Lee; Glenys Dore; Lisa Juckes; Tamara De Regt; Sharon L Naismith; Jim Lagopoulos; Ashleigh Tickell; Ian B Hickie; Daniel F Hermens

doi:10.1080/13546805.2015.1014031

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Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder

Journal article

Peer reviewed

Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder

Rico S Lee, Glenys Dore, Lisa Juckes, Tamara De Regt, Sharon L Naismith, Jim Lagopoulos, Ashleigh Tickell, Ian B Hickie and Daniel F Hermens

Cognitive Neuropsychiatry, Vol.20(3), pp.222-231

2015

DOI: https://doi.org/10.1080/13546805.2015.1014031

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Abstract

Medical and Health Sciences

Psychology and Cognitive Sciences

neuropsychology

cognitive deficits

alcohol dependence

detoxification

disability

Introduction. Little is known about the relationship between cognitive dysfunction and functional disability in alcohol dependence with comorbid affective disorders. We investigated the neuropsychology of alcohol dependence in detoxified adults with and without affective comorbidity and examined the factors associated with prolonged functional disability. Methods. From a total of 42 participants (age range = 18-44 years), 12 out of 21 alcohol-dependent participants had a comorbid affective disorder, 12 had an affective disorder only, and 9 were healthy controls. Participants completed a semi-structured clinical interview, questionnaires and comprehensive neuropsychological assessment. Results. Following detoxification (median = 35 days; M = 41.2 days, SD = 17.9), visual learning and memory functioning was worse in alcohol-dependent individuals. Comorbid affective disorders did not appear to exacerbate cognitive dysfunction. Psychiatric comorbidity and current depressive symptoms were predictive of poorer functional disability. Furthermore, learning and memory, and response inhibition, contributed significantly and independently to predicting functional disability over and above clinical and demographic factors. Conclusions. Psychiatric comorbidity does not appear to be associated with more pronounced neuropsychological dysfunction in alcohol dependence. Conversely, both comorbid affective disorders and cognitive factors were critical in determining the functional outcomes of alcohol-dependent adults recently undergoing medically supervised inpatient detoxification.

Details

Title: Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder
Authors: Rico S Lee (Author) - University of Sydney
Glenys Dore (Author) - Royal North Shore Hospital
Lisa Juckes (Author) - Royal North Shore Hospital
Tamara De Regt (Author) - University of Sydney
Sharon L Naismith (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
Ashleigh Tickell (Author) - University of Sydney
Ian B Hickie (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Publication details: Cognitive Neuropsychiatry, Vol.20(3), pp.222-231
Publisher: Routledge
Date published: 2015
DOI: 10.1080/13546805.2015.1014031
ISSN: 1354-6805
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; Thompson Institute; Engage Research Lab; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449912502621
Output Type: Journal article

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Web Of Science research areas: Psychiatry

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