Logo image
Back
Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens
Journal article   Peer reviewed

Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens

Peter Timms, N P Stewart, B J Rodwell and D N Barry
Veterinary Parasitology, Vol.16(3-4), pp.243-251
1984
DOI: https://doi.org/10.1016/0304-4017(84)90042-6
url
https://doi.org/10.1016/0304-4017(84)90042-6View
Published Version

Abstract

Twenty-four yearling Hereford (Bos taurus) cattle were vaccinated against Babesia bovis using either live parasites or non-living antigens obtained from the supernatant of in vitro cultures. A single dose of live parasites was given subcutaneously, while the non-living supernatant antigen (NLSA) was combined with saponin and 2 doses given, 2 weeks apart. Following vaccination with live parasites, serum antibodies remained at high levels for 6 months, but the lymphocyte transformation response was low and lasted only 10-18 days. In contrast, NLSA vaccination was followed, after 21-28 days, by a peak of serum antibodies which then slowly declined. The lymphocyte transformation response in these animals was much higher and persisted for 6 months. Following heterologous challenge all unvaccinated cattle had severe reactions and required treatment to prevent death. Cattle vaccinated with live parasites had mild reactions with only 1 of the 12 requiring treatment. Cattle vaccinated with NLSA were only partially protected and 6 of the 12 required treatment. © 1984.

Details

Metrics

739 Record Views
24 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas
Parasitology
Veterinary Sciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Logo image