Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens

Peter Timms; N P Stewart; B J Rodwell; D N Barry

doi:10.1016/0304-4017(84)90042-6

Back

Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens

Journal article

Peer reviewed

Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens

Peter Timms, N P Stewart, B J Rodwell and D N Barry

Veterinary Parasitology, Vol.16(3-4), pp.243-251

1984

DOI: https://doi.org/10.1016/0304-4017(84)90042-6

Files and links (1)

url

https://doi.org/10.1016/0304-4017(84)90042-6View

Published Version

Abstract

Twenty-four yearling Hereford (Bos taurus) cattle were vaccinated against Babesia bovis using either live parasites or non-living antigens obtained from the supernatant of in vitro cultures. A single dose of live parasites was given subcutaneously, while the non-living supernatant antigen (NLSA) was combined with saponin and 2 doses given, 2 weeks apart. Following vaccination with live parasites, serum antibodies remained at high levels for 6 months, but the lymphocyte transformation response was low and lasted only 10-18 days. In contrast, NLSA vaccination was followed, after 21-28 days, by a peak of serum antibodies which then slowly declined. The lymphocyte transformation response in these animals was much higher and persisted for 6 months. Following heterologous challenge all unvaccinated cattle had severe reactions and required treatment to prevent death. Cattle vaccinated with live parasites had mild reactions with only 1 of the 12 requiring treatment. Cattle vaccinated with NLSA were only partially protected and 6 of the 12 required treatment. © 1984.

Details

Title: Immune responses of cattle following vaccination with living and non-living Babesia bovis antigens
Authors: Peter Timms (Author) - Queensland Department of Primary Industries
N P Stewart (Author) - Queensland Department of Primary Industries
B J Rodwell (Author) - Queensland Department of Primary Industries
D N Barry (Author) - Queensland Department of Primary Industries
Publication details: Veterinary Parasitology, Vol.16(3-4), pp.243-251
Publisher: Elsevier BV
DOI: 10.1016/0304-4017(84)90042-6
ISSN: 0304-4017
Organisation Unit: Centre for Bioinnovation; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449652802621
Output Type: Journal article

Metrics

723 Record Views

24 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Parasitology; Veterinary Sciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites