Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters

B Grech; S Mathews; Peter Timms

doi:10.1016/j.resmic.2008.07.002

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Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters

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Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters

B Grech, S Mathews and Peter Timms

Research in Microbiology, Vol.159(7-8), pp.550-556

2008

DOI: https://doi.org/10.1016/j.resmic.2008.07.002

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Abstract

Chlamydia

gene expression regulation

genetic transcription

molecular evolution

phylogenetic footprinting

promoter regions

We used four different phylogenetic footprinting programs and the six chlamydial species with publicly available whole genome sequences to analyze the 12 known Ïƒ66 promoters of Chlamydia trachomatis that phylogenetically footprinted negative in our previous paper. The analysis showed that 7 of the 12 promoters were poorly conserved across C. trachomatis, Chlamydia pneumoniae and Chlamydia caviae. Interestingly, the associated gene sets for these seven promoters were homologs and the gene orders were well conserved across these three species. Additional phylogenetic footprinting, across different subsets from that used above, of the six publicly available whole chlamydial genome sequences and transcription initiation site mapping of chlamydial promoters was also performed. This analysis showed that two of the seven poorly conserved promoters, the promoters in the upstream regions of C. caviae ltuA and ltuB, were like Escherichia coli Ïƒ70 promoters. Therefore, these promoters are similar to the promoters of C. trachomatis ltuA and ltuB, as they are Ïƒ70-like. Given the fact that 7 out of the 22 known Ïƒ66 promoters in C. trachomatis are poorly conserved across C. trachomatis, C. pneumoniae and C. caviae, we would like to suggest that many other chlamydial promoters are poorly conserved across these species. © 2008 Elsevier Masson SAS. All rights reserved.

Details

Title: Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters
Authors: B Grech (Author) - Queensland University of Technology
S Mathews (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
Publication details: Research in Microbiology, Vol.159(7-8), pp.550-556
Publisher: Elsevier Masson
Date published: 2008
DOI: 10.1016/j.resmic.2008.07.002
ISSN: 0923-2508; 0923-2508
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449043502621
Output Type: Journal article

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