The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury

Yoke Lin Fung; C C Silliman

doi:10.1016/j.tmrv.2009.06.001

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The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury

Journal article

Open access

Peer reviewed

The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury

Yoke Lin Fung and C C Silliman

Transfusion Medicine Reviews, Vol.23(4), pp.266-283

2009

DOI: https://doi.org/10.1016/j.tmrv.2009.06.001

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Abstract

alloantibody

blood donor

host leukocytes

neutrophil

TRALI

Transfusion-related acute lung injury (TRALI) is the major cause of transfusion related morbidity and mortality, world wide. Efforts to reduce or eliminate this serious complication of blood transfusion are hampered by an incomplete understanding of its pathogenesis. Currently, TRALI is thought to be mediated by donor alloantibodies directed against host leukocytes or the result of 2 distinct clinical events. For both proposed mechanisms, the neutrophil is the key effector cell. This article reviews TRALI pathophysiology, explores the role of the neutrophil, details practical information for appropriate diagnosis and promotes further studies into the pathogenesis of TRALI. © 2009 Elsevier Inc.

Details

Title: The Role of Neutrophils in the Pathogenesis of Transfusion-Related Acute Lung Injury
Authors: Yoke Lin Fung (Author) - Australian Red Cross Blood Service
C C Silliman (Author) - University of Colorado, United States
Publication details: Transfusion Medicine Reviews, Vol.23(4), pp.266-283
Publisher: W.B. Saunders Co.
Date published: 2009
DOI: 10.1016/j.tmrv.2009.06.001
ISSN: 0887-7963
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99447767402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Hematology

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