${session.getAttribute("locale")} 5 Transfusion of packed red blood cells reduces selenium levels and increases lipid peroxidation in an in vivo ovine model Wed 23 Aug 2017 12:56:18 AEST ]]> Crystalloid vs colloid at the cellular level of oxygenation: a randomised controlled study of haemorrhagic shock in an ovine model Wed 23 Aug 2017 12:56:16 AEST ]]> Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage Wed 23 Aug 2017 12:56:15 AEST ]]> What are the best markers of essential tissue hypoperfusion in haemorrhagic shock? Wed 23 Aug 2017 12:56:13 AEST ]]> Transfusion of fresh or aged red cells after haemorragic shock reduces selenium and glutathione peroxidase Wed 23 Aug 2017 12:56:13 AEST ]]> Does the haemoglobin level of older blood donors change with age? A multi-centre retrospective observational study Wed 21 Aug 2019 13:36:42 AEST ]]> Pilot study investigating if age appropriate coagulation reference ranges are required to support patient blood management in the elderly Wed 21 Aug 2019 13:36:39 AEST ]]> Recent evidence favours specific guidance on transfusion strategies in the older population Wed 17 Jan 2018 08:03:04 AEST ]]> Who is using blood and when - impact of the ageing population on demand for and urgency of transfusion Wed 17 Jan 2018 08:03:04 AEST ]]> Questioning the benefit of restrictive transfusion practice in older adults 18 years of age have concluded that restrictive practice is noninferior to liberal transfusion approaches. A restrictive approach to transfusion reduces resource consumption and cost, as well as the hazards associated with unnecessary exposure to blood products. Although adults aged ≥65 years consume over half of the blood supply, there are few randomized controlled transfusion trials exclusive to this cohort. Our 2017 meta‐analysis of a small number of trials focussed on older adults found that higher transfusion haemoglobin thresholds were associated with lower mortality and fewer cardiac complications in this age group. Other studies have also shown that higher transfusion haemoglobin thresholds are beneficial in older adults. This paper presents recent evidence regarding transfusion outcomes in older adults and discusses aspects of the pathophysiology of ageing that impact on the reduced resilience of older patients to anaemic states. This evidence challenges the use of Hb thresholds that apply across the adult lifespan, regardless of age. It proposes that older age be considered as a risk factor in assessing transfusion requirements, and that transfusion practice in older adults may require higher haemoglobin thresholds than for younger adults.]]> Wed 13 Mar 2019 15:29:46 AEST ]]> Clinical and quality of life impacts of IVIg and SCIg therapy differ in patients with secondary immunodeficiency compared to those with primary immunodeficiency Tue 30 Jul 2019 11:23:43 AEST ]]> Cost–utility analysis comparing hospital‐based intravenous immunoglobulin with home‐based subcutaneous immunoglobulin in patients with secondary immunodeficiency Tue 23 Apr 2019 10:18:47 AEST ]]> Optimal management of the critically Ill: Anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care Tue 22 Aug 2017 11:16:08 AEST ]]> Authors' reply to comment “Blood transfusion strategies in elderly patients” Tue 21 Nov 2017 14:18:53 AEST ]]> Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury Tue 21 Jul 2015 15:19:42 AEST ]]> Subcutaneous Immunoglobulin Therapy for Hypogammaglobulinemia Secondary to Malignancy or Related Drug Therapy Tue 12 Dec 2017 15:35:54 AEST ]]> The impact of Acute Lung Injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model Tue 10 Jan 2017 12:26:25 AEST ]]> Oxidative stress during extracorporeal circulation Tue 02 Jun 2015 09:45:48 AEST ]]> A comprehensive ovine model of blood transfusion Tue 02 Jun 2015 09:45:44 AEST ]]> Evidence of ECMO induced changes to haemostasis in an ovine model Tue 02 Jun 2015 09:45:42 AEST ]]> Implementing a point of care testing (POCT) service improves management of haemostatic dysfunction in cardiac surgery patients Tue 02 Jun 2015 09:45:40 AEST ]]> Subcutaneous immunoglobulin in patients with common variable immunodeficiency Thu 29 Nov 2018 12:00:26 AEST ]]> Lessons from sheep models of transfusion Thu 23 Mar 2017 11:40:08 AEST ]]> Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support 65 mmHg. Results: Rotational thromboelastometry, platelet aggregometry and routine coagulation laboratory tests demonstrated that S-ALI and ECMO independently induced changes to platelet function, delayed clot formation and reduced clot firmness. This effect was augmented with the combination of S-ALI and ECMO, with evidence of increased collagen-induced platelet aggregation as well as changes in factor VIII (FVIII), factor XII and fibrinogen levels. Conclusions: The introduction of an ECMO circuit itself increases collagen-induced platelet aggregation, decreases FVIII and von Willebrand factor, and induces a transient decrease in fibrinogen levels and function in the first 24 h. These changes to haemostasis are amplified when a host with a pre-existing pulmonary injury is placed on ECMO. Because patients are often on ECMO for extended periods, longer-duration studies are required to characterise ECMO-induced haemostatic changes over the long term. The utility of point-of-care tests for guiding haemostatic management during ECMO also warrants further exploration. © 2017 The Author(s).]]> Thu 22 Mar 2018 10:26:40 AEST ]]> Baa Baa Blood Sheep Thu 17 Nov 2016 14:29:40 AEST ]]> Protein bound drugs are prone to sequestration in ECMO circuits: results from an ex vivo experiment Thu 17 Nov 2016 14:01:52 AEST ]]> Primary immunodeficiency disease: a cost-utility analysis comparing intravenous vs subcutaneous immunoglobulin replacement therapy in Australia Thu 15 Aug 2019 15:25:48 AEST ]]> Non-antibody mediated transfusion-related acute lung injury an enigma Thu 15 Aug 2019 15:18:42 AEST ]]> Antioxidant Trace Element Reduction in an In Vitro Cardiopulmonary Bypass Circuit Thu 14 May 2015 10:13:54 AEST ]]> External quality assessment of human neutrophil antigen (HNA)-specific antibody detection and HNA genotyping from 2000 to 2012 Thu 14 May 2015 10:13:53 AEST ]]> Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology Thu 14 May 2015 10:13:52 AEST ]]> The fundamentals of neutrophil antigen and antibody investigations Thu 14 May 2015 10:13:51 AEST ]]> ECMO – the clinician’s view Thu 14 May 2015 10:13:45 AEST ]]> Transfusion-related acute lung injury investigation insights Thu 14 May 2015 10:13:45 AEST ]]> Evidence behind the pathophysiology of TRALI Thu 14 May 2015 10:13:41 AEST ]]> Clinical scale ex vivo manufacture of neutrophils from hematopoietic progenitor cells Thu 14 May 2015 10:13:39 AEST ]]> Extracorporeal lessons from sheep Thu 14 May 2015 10:13:38 AEST ]]> A novel in vivo ovine model of transfusion-related acute lung injury (TRALI) Thu 14 May 2015 10:06:52 AEST ]]> Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia Thu 14 May 2015 10:06:44 AEST ]]> Neutrophil antibody diagnostics and screening: Review of the classical versus the emerging Thu 14 May 2015 10:06:38 AEST ]]> How different animal models help us understand TRALI Thu 06 Sep 2018 10:08:22 AEST ]]> Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions Mon 27 Jun 2016 11:33:47 AEST ]]> A retrospective explanatory case study of the implementation of a bleeding management quality initiative, in an Australian cardiac surgery unit Mon 18 Mar 2019 11:26:44 AEST ]]> Preliminary Findings from an Ovine Model of Blood Component Therapy Developed to Investigate Transfusion-Related Acute Lung Injury Mon 06 Jan 2020 13:58:16 AEST ]]> Protocol Guided Bleeding Management Improves Cardiac Surgery Patient Outcomes Mon 02 Nov 2015 09:35:03 AEST ]]> Blood management in hip fractures; are we leaving it too late? A retrospective observational study Mon 01 Apr 2019 15:31:44 AEST ]]> Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study Fri 30 Aug 2019 13:31:46 AEST ]]> Osteopontin alters endothelial and valvular interstitial cell behaviour in calcific aortic valve stenosis through HMGB1 regulation Fri 27 Apr 2018 16:48:50 AEST ]]> Improving Economic Accountability for Blood Products: TPCH Experience Fri 27 Apr 2018 16:48:50 AEST ]]> Neutrophil Antibodies are clinically important Fri 24 Apr 2015 15:23:39 AEST ]]> How do you solve a problem like transfusion-related acute lung injury? Fri 24 Apr 2015 13:03:40 AEST ]]> Outcomes of restrictive versus liberal transfusion strategies in older adults from nine randomised controlled trials: a systematic review and meta-analysis Fri 23 Mar 2018 13:02:39 AEST ]]> A standardized immunofluorescence test method with human neutrophil antigen-expressing cell lines to enhance antibody detection Fri 22 Nov 2019 07:34:44 AEST ]]> Neutrophil antibody detection using transfected K562 cells expressing human neutrophil antigens Fri 22 Nov 2019 07:34:38 AEST ]]> Inflammation and Lung Injury in an Ovine Model of Extracorporeal Membrane Oxygenation Support Fri 22 Jun 2018 10:02:56 AEST ]]> Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock Fri 22 Feb 2019 15:32:43 AEST ]]> Low preoperative selenium is associated with post-operative atrial fibrillation in patients having intermediate-risk coronary artery surgery Fri 16 Dec 2016 14:34:19 AEST ]]> Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation Fri 08 Apr 2016 09:49:12 AEST ]]> Massive haemorrhage and transfusions each change coagulation plasma factors Fri 08 Apr 2016 09:30:49 AEST ]]> Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models Fri 08 Apr 2016 09:17:10 AEST ]]> Blood product storage age and type determine pathophysiology of TRALI Fri 08 Apr 2016 08:34:08 AEST ]]> The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation Fri 08 Apr 2016 08:00:11 AEST ]]> ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO Fri 08 Apr 2016 07:58:39 AEST ]]> Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI) Fri 08 Apr 2016 07:47:40 AEST ]]> Sedation during extracorporeal membrane oxygenation—why more is less Fri 08 Apr 2016 07:46:06 AEST ]]> Optimal meropenem exposure may be achieved with standard doses in patients receiving extracorporeal membrane oxygenation (ECMO) Fri 08 Apr 2016 07:41:37 AEST ]]> ECMO has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep Fri 08 Apr 2016 06:42:21 AEST ]]> A comparison of the storage lesions of ovine and human packed red blood cell units Fri 07 Nov 2014 15:23:44 AEST ]]> Point of care coagulation and platelet function testing: implementation of a new service in a tertiary cardiac surgery unit Fri 07 Nov 2014 15:23:16 AEST ]]> A pilot study on the incidence of HLA class I, Class II and HNA antibodies in Australian Apheresis Donors Fri 07 Nov 2014 15:22:26 AEST ]]> The pivotal role of neutrophils in the pathology and investigation of TRALI Fri 07 Nov 2014 15:19:57 AEST ]]> Trace elements and the cardiopulmonary bypass circuit Fri 07 Nov 2014 15:12:24 AEST ]]> Consensus defined TRALI cases with and without leukocyte antibodies Fri 07 Nov 2014 15:05:24 AEST ]]> Its not just about TRALI: The Clinical Significance of Neutrophils Fri 07 Nov 2014 15:04:04 AEST ]]> Acute lung injury compounds ECMO-induced changes to haemostasis in an ovine model Fri 07 Nov 2014 14:51:41 AEST ]]> Dealing with blood donations from a female donor with a rare case of alloimmune neonatal neutropenia (ANN) due to anti-FcRIIIb Fri 07 Nov 2014 14:38:28 AEST ]]> Seeding of Biosynthetic Heart Valves with Endothelial Cells Derived From Sheep Circulating Mononuclear Cells Fri 07 Nov 2014 14:32:18 AEST ]]> Developments in the detection of HNA and HLA antibodies Fri 07 Nov 2014 14:31:10 AEST ]]> What's new with TRALI Fri 07 Nov 2014 14:31:00 AEST ]]> Recipient T and B Lymphocytes Dictate the Severity of Antibody-Mediated Transfusion-Related Acute Lung Injury (TRALI) Fri 07 Nov 2014 14:12:52 AEST ]]> A validated ovine model for blood collection, processing, compatibility testing and transfusion Fri 07 Nov 2014 14:01:15 AEST ]]> Dissimilar Respiratory and Hemodynamic Responses In TRALI Induced by Stored Red Cells and Whole Blood Platelets. Fri 07 Nov 2014 14:01:13 AEST ]]> Is Morphine Superior to Fentanyl for Analgesia during Extracorporeal Membrane Oxygenation in Adult Patients? Fri 07 Nov 2014 13:51:45 AEST ]]> The Sheep as a Transfusion Model: Comparison of the Storage Lesion of Human and Ovine Red Blood Cell Units Fri 07 Nov 2014 13:49:56 AEST ]]> Preliminary findings on how ECMOdisrupts haemostasis: an ovine model Fri 07 Nov 2014 13:44:58 AEST ]]> Preliminary results of routine coagulation parameters during ECMO in an ovine model Fri 07 Nov 2014 13:43:25 AEST ]]> Preliminary histological evidence that red cell transfusions exacerbate lung injury in an ovine ecmo model Fri 07 Nov 2014 13:42:17 AEST ]]> Tracking ECMO induced changes to Haemostasis with Rotem® and Multiplate® analyser in an Ovine model Fri 07 Nov 2014 13:31:03 AEST ]]> A comprehensive study of ovine haemostasis to assess suitability to model human coagulation Fri 07 Nov 2014 13:24:56 AEST ]]> Anti-HNA-2a antibodies implicated in TRALI and ANN demonstrate serological variability and different epitope preferences 70%) using both the granulocyte immunofluorescence test (GIFT) and granulocyte agglutination test (GAT). Two clones of CD177 (7D8 and MEM-166) were applied in the monoclonal antibody immobilization of granulocyte antigens assay (MAIGA). These same monoclonal antibodies (Mab) were used in blocking studies for epitope mapping, against PMNs from two individuals determined to have high (>70%) and two individuals with moderate (30-70%) HNA-2a expression. Results: Only 2/3 of TRALI associated sera and 1/2 of ANN sera were MAIGA positive (i.e. captured by the CD177 clones). The MAIGA negative sera (TW and AB) had higher titers. PMNs pre-treated with both MAIGA negative sera reduced subsequent 7D8 binding but only partially reduced MEM-166 binding. This suggests that the Abs in these two sera were directed to a site closer to the 7D8 epitope. Although sera TQ, TS and AS were captured by both MAb, pre-treament with TS did not block subsequent MAb binding. And TQ and AS only demonstrated partial blocking. PMNs pre-treated with these MAbs did not reduce subsequent binding of Abs from all 5 sera (data not shown). These data indicate that the Abs in the sera bound to HNA-2a at more epitopes than the two tested. Conclusions: These data did not identify any characteristic that differentiated ANN from TRALI implicated Abs. They revealed differences in GIFT and GAT titers, and significant serological and epitope preference variability. These serological differences in characteristics may influence the severity of antibody mediated events such as TRALI. These observations justify further studies to characterize Abs implicated in TRALI events, such as Ab titers, isotype, subtypes and epitope reactivity.]]> Fri 07 Nov 2014 13:24:52 AEST ]]> Sheep red blood cells for transfusion: is the storage lesion comparable to human red blood cells? Fri 07 Nov 2014 13:18:00 AEST ]]> Red cell and albumin resuscitation following acute massive haemorrhage alters haemostasis Fri 07 Nov 2014 13:15:42 AEST ]]> A novel in-vivo ovine model of transfusion-related acute lung injury (TRALI) Fri 07 Nov 2014 13:06:44 AEST ]]> Preliminary findings from an ovine model of blood component therapy developed to investigate transfusion-related acute lung injury Fri 07 Nov 2014 13:04:46 AEST ]]> ECMO contributes to lung injury in an ovine model of veno-venous ECMO Fri 07 Nov 2014 13:02:38 AEST ]]> Non-immune TRALI Fri 07 Nov 2014 12:57:11 AEST ]]> Massive haemorrhage and transfusions each change coagulation plasma factor function Fri 07 Nov 2014 12:56:17 AEST ]]> Transfusion-related acute lung injury (TRALI) in a two-event ovine model following transfusion with supernatant from stored human packed red blood cell components Fri 07 Nov 2014 12:53:26 AEST ]]> The ovine packed red blood cell storage lesion: characterisation and comparison to that of human packed red blood cells Fri 07 Nov 2014 12:52:10 AEST ]]> Impacts of Aging on Anemia Tolerance, Transfusion Thresholds and Patient Blood Management Fri 06 Sep 2019 13:38:40 AEST ]]>