${session.getAttribute("locale")} 5 A Pilot Randomized Controlled Trial of the Feasibility, Acceptability, and Impact of Giving Information on Personalized Genomic Risk of Melanoma to the Public Wed 14 Mar 2018 14:01:40 AEST ]]> The impact of body mass index and physical activity on mortality among patients with colorectal cancer in Queensland, Australia 2 hour per week: HR = 0.64 (0.44-0.93) and 31% for all-cause mortality (increase >2 hour per week: HR = 0.69 (0.50-0.94). Compared with participants with healthy BMI, significant higher mortality risk was observed in underweight patients (all-cause: HR = 2.29 (1.47-3.59); CRC: HR = 1.74 (1.00-3.04), although lower risk in overweight (all-cause: HR = 0.75 (0.61-0.94); CRC: HR = 0.75 (0.59-0.97) and no difference in obese. Excessive weight loss was associated with increased mortality risk by three-fold but no difference in those who gained weight. Conclusions: Protective effects of being physically active and increasing that activity underlines the importance of interventions to increase activity levels among people being diagnosed with CRC. Impact: Increased mortality risks associated with being underweight or having weight loss over time is an important indicator for which clinicians, patients, and support personnel can monitor. ©2011 AACR.]]> Tue 18 Apr 2017 14:34:34 AEST ]]> Antitumor Activity of 3-Ingenyl Angelate Plasma Membrane and Mitochondrial Disruption and Necrotic Cell Death 14 tumors/group) and human tumors (DO4 melanoma, HeLa cervical carcinoma, and PC3 and DU145 prostate carcinoma; n = >4 tumors/group) previously established (5–10 mm3) on C57BL/6 or Foxn1nu mice. The treatment produced a mild, short-term erythema and eschar formation but, ultimately, resulted in excellent skin cosmesis. The LD90 for PEP005 for a panel of tumor cell lines was 180–220 μm. Electron microscopy showed that treatment with PEP005 both in vitro (230 μm) and in vivo (42 nmol) rapidly caused swelling of mitochondria and cell death by primary necrosis. 51Cr release, uptake of propidium iodide, and staining with the mitochondria dye JC1, revealed that PEP005 (230 μm) treatment of tumor cells in vitro resulted in a rapid plasma membrane perturbation and loss of mitochondrial membrane potential. PEP005 thus emerges as a new topical anti-skin cancer agent that has a novel mode of action involving plasma membrane and mitochondrial disruption and primary necrosis, ultimately resulting in an excellent cosmetic outcome.]]> Tue 16 Oct 2018 12:41:53 AEST ]]> Induction of Senescence in Diterpene Ester–Treated Melanoma Cells via Protein Kinase C–Dependent Hyperactivation of the Mitogen-Activated Protein Kinase Pathway Tue 16 Oct 2018 12:33:53 AEST ]]> Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells Tue 16 Oct 2018 12:33:41 AEST ]]> Candidate genetic modifiers for breast and ovarian cancer risk inBRCA1andBRCA2 mutation carriers Tue 02 Aug 2016 16:11:25 AEST ]]> Genome-wide association study identifies a possible susceptibility locus for endometrial cancer Tue 02 Aug 2016 15:50:24 AEST ]]> Assessment of lifetime cumulative sun exposure using a self-administered questionnaire: Reliability of two approaches Thu 16 Apr 2015 13:14:45 AEST ]]> Risk analysis of prostate cancer in practical, a multinational consortium, using 25 known prostate cancer susceptibility loci Thu 05 Oct 2017 16:35:55 AEST ]]> Polymorphisms in inflammation pathway genes and endometrial cancer risk Thu 05 Oct 2017 16:27:46 AEST ]]> Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis Thu 05 Oct 2017 16:11:33 AEST ]]> Knowledge and attitudes about vitamin D and impact on sun protection practices among urban office workers in Brisbane, Australia Fri 08 Apr 2016 07:41:07 AEST ]]>