${session.getAttribute("locale")} 5 Response to Dr Fried & Dr Kievit, and Dr Malhi et al Wed 27 Nov 2019 13:55:45 AEST ]]> Subcortical brain structure and suicidal behaviour in major depressive disorder: A meta-analysis from the ENIGMA-MDD working group Wed 27 Nov 2019 12:59:39 AEST ]]> Response to Dr Fried & Dr Kievit, and Dr Malhi et al. [Size matters; but so does what you do with it!] Tue 25 Jun 2019 13:15:39 AEST ]]> Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group Tue 10 Mar 2020 11:30:25 AEST ]]> Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned 1 M imputed single-nucleotide polymorphisms (SNPs)). No SNPs achieved genome-wide significance either in the MDD2000+ study, or in meta-analysis with two other studies totaling 5763 cases and 6901 controls. These results imply that common variants of intermediate or large effect do not have main effects in the genetic architecture of MDD. Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). We estimate that sample sizes 1.8- to 2.4-fold greater are needed for association studies of MDD compared with those for schizophrenia to detect variants that explain the same proportion of total variance in liability. Larger study cohorts characterized for genetic and environmental risk factors accumulated prospectively are likely to be needed to dissect more fully the etiology of MDD.]]> Fri 13 Mar 2020 09:37:23 AEST ]]> Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group 21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: −0.26 to −0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.Molecular Psychiatry advance online publication, 3 May 2016; doi:10.1038/mp.2016.60. © 2016 Macmillan Publishers Limited]]> Fri 07 Feb 2020 16:21:49 AEST ]]>