${session.getAttribute("locale")} 5 Adaptation and conservation insights from the koala genome Wed 18 Mar 2020 08:48:43 AEST ]]> SNP Marker Discovery in Koala TLR Genes Wed 18 Mar 2020 08:48:07 AEST ]]> Characterisation of MHC class I genes in the koala Wed 18 Mar 2020 08:44:52 AEST ]]> Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii) 30%). Phylogenetic analysis shows that gene duplication has driven unique and species-specific expansions of devil, koala, and tammar wallaby beta defensins and devil alpha defensins. Defensin genes are arranged in three genomic clusters in marsupials, whereas further duplications and translocations have occurred in eutherians resulting in four and five gene clusters in mice and humans, respectively. Marsupial defensins are generally under purifying selection, particularly residues essential for defensin structural stability. Certain hydrophobic or positively charged sites, predominantly found in the defensin loop, are positively selected, which may have functional significance in defensin-target interaction and membrane insertion.]]> Wed 05 Apr 2017 15:00:34 AEST ]]>