${session.getAttribute("locale")} 5 Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study 200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. Methods: GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. Results: 1086 isolates from 31 countries were analysed, representing 175 emm-types. Emm-type is predictive of the whole protein structure, independent of geographic origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats, and predicted secondary structure was assessed in the context of the latest vaccine developments. Conclusions: Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80, M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies.]]> Wed 18 Mar 2020 09:09:02 AEST ]]> Babesia bovis: Evidence for selection of subpopulations during attenuation Wed 18 Mar 2020 08:48:46 AEST ]]> CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target Wed 18 Mar 2020 08:46:50 AEST ]]> Burkholderia pseudomallei lipopolysaccharide genotype does not correlate with severity or outcome in melioidosis: host risk factors remain the critical determinant Wed 18 Mar 2020 08:31:17 AEST ]]> Genomic epidemiology of severe community-onset Acinetobacter baumannii infection Wed 18 Mar 2020 08:29:28 AEST ]]> First description of ‘Chalky back’ phenomenon in banana prawns (Fenneropenaeus merguiensis) and its possible association with Vibrio and Photobacterium species Wed 18 Mar 2020 08:16:15 AEST ]]> Prevalence and Persistence of Escherichia coli Strains with Uropathogenic Virulence Characteristics in Sewage Treatment Plants Wed 18 Mar 2020 08:05:23 AEST ]]> Interaction of Aeromonas strains with lactic acid bacteria using Caco-2 cells Wed 18 Mar 2020 08:04:30 AEST ]]>