${session.getAttribute("locale")} 5 Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome Tue 16 Oct 2018 12:27:18 AEST ]]> Selection against amino acid replacements in human proteins Tue 16 Oct 2018 12:17:15 AEST ]]> Second generation DNA sequencing of the mitogenome of the Chinstrap penguin and comparative genomics of Antarctic penguins Tue 16 Oct 2018 12:16:28 AEST ]]> Temporal trails of natural selection in human mitogenomes Tue 16 Oct 2018 12:03:03 AEST ]]> Gene expression intensity shapes evolutionary rates of the proteins encoded by the vertebrate genome Tue 16 Oct 2018 12:02:51 AEST ]]> Fixation of deleterious mutations at critical positions in human proteins Tue 16 Oct 2018 11:13:04 AEST ]]> High proportions of deleterious polymorphisms in constrained human genes 14,000 human-chimp nuclear genes and 1 million SNPs from four human genomes showed a significant proportion of deleterious nonsynonymous SNPs (∼15%). Importantly, this study reveals a negative correlation between the magnitude of selection pressure and the proportion of deleterious SNPs on human genes. The proportion of deleterious amino acid replacement polymorphisms is 3.5 times higher in genes under high purifying selection compared with that in less constrained genes (28% vs. 8%). These results are explained by differences in the extent of contribution of mildly deleterious mutations to diversity and substitution. © 2010 The Author.]]> Tue 16 Oct 2018 11:12:55 AEST ]]> Time dependency of molecular evolutionary rates? Yes and no Tue 16 Oct 2018 11:12:46 AEST ]]> Selective constraints determine the time dependency of molecular rates for human nuclear genomes Tue 16 Oct 2018 11:12:16 AEST ]]> Ancient Population Genomics Mon 14 Jan 2019 07:54:04 AEST ]]> How sexual and natural selection shape sexual size dimorphism: evidence from multiple evolutionary scales Mon 12 Aug 2019 12:38:39 AEST ]]>