http://research.usc.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Questioning the benefit of restrictive transfusion practice in older adults http://research.usc.edu.au/vital/access/manager/Repository/usc:26912 18 years of age have concluded that restrictive practice is noninferior to liberal transfusion approaches. A restrictive approach to transfusion reduces resource consumption and cost, as well as the hazards associated with unnecessary exposure to blood products. Although adults aged ≥65 years consume over half of the blood supply, there are few randomized controlled transfusion trials exclusive to this cohort. Our 2017 meta‐analysis of a small number of trials focussed on older adults found that higher transfusion haemoglobin thresholds were associated with lower mortality and fewer cardiac complications in this age group. Other studies have also shown that higher transfusion haemoglobin thresholds are beneficial in older adults. This paper presents recent evidence regarding transfusion outcomes in older adults and discusses aspects of the pathophysiology of ageing that impact on the reduced resilience of older patients to anaemic states. This evidence challenges the use of Hb thresholds that apply across the adult lifespan, regardless of age. It proposes that older age be considered as a risk factor in assessing transfusion requirements, and that transfusion practice in older adults may require higher haemoglobin thresholds than for younger adults.]]> Wed 13 Mar 2019 15:29:46 AEST ]]> Emergency Department presentation of frail older people and interventions for management: Geriatric Emergency Department Intervention http://research.usc.edu.au/vital/access/manager/Repository/usc:22483 Mon 26 Mar 2018 09:45:39 AEST ]]> The Geriatric Emergency Department Intervention model of care: a pragmatic trial http://research.usc.edu.au/vital/access/manager/Repository/usc:27861 Fri 06 Sep 2019 13:40:44 AEST ]]> A structure, process and outcome evaluation of the Geriatric Emergency Department Intervention model of care: a study protocol http://research.usc.edu.au/vital/access/manager/Repository/usc:22269 Fri 06 Sep 2019 13:40:23 AEST ]]> Impacts of Aging on Anemia Tolerance, Transfusion Thresholds and Patient Blood Management http://research.usc.edu.au/vital/access/manager/Repository/usc:28499 Fri 06 Sep 2019 13:38:40 AEST ]]>