${session.getAttribute("locale")} 5 Temporal trails of natural selection in human mitogenomes Tue 16 Oct 2018 12:03:03 AEST ]]> Influence of Effective Population Size on Genes under Varying Levels of Selection Pressure Tue 16 Oct 2018 11:49:19 AEST ]]> Fixation of deleterious mutations at critical positions in human proteins Tue 16 Oct 2018 11:13:04 AEST ]]> Quantifying harmful mutations in human populations 77 000 SNPs from human protein-coding genes were analyzed. Based on two independent methods, this study reveals that up to 53% of rare nSNPs (minor allele frequency (MAF)<0.002) could be deleterious in nature. The fraction of deleterious nSNPs declines with the increase in their allele frequencies and only 12% of the common nSNPs (MAF>0.4) were found to be harmful. This shows that even at high frequencies significant fractions of deleterious polymorphisms are present in human populations. These results could be useful for genome-wide association studies in understanding the relative contributions of rare and common variants in causing human genetic diseases. © 2012 Macmillan Publishers Limited All rights reserved.]]> Tue 16 Oct 2018 11:12:22 AEST ]]>