${session.getAttribute("locale")} 5 Sniffing out solutions to enhance conservation: How detection dogs can maximise research and management outcomes, through the example of koalas Wed 31 Jul 2019 13:31:39 AEST ]]> Chlamydia antigens and uses therof Tue 25 Jun 2019 15:59:17 AEST ]]> Current trends and future directions in koala chlamydial disease research Tue 24 Oct 2017 09:38:53 AEST ]]> Characterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon Tue 16 Oct 2018 12:31:07 AEST ]]> Immunization of a wild koala population with a recombinant Chlamydia pecorum Major Outer Membrane Protein (MOMP) or Polymorphic Membrane Protein (PMP) based vaccine: New insights into immune response, protection and clearanc Tue 16 Oct 2018 12:28:17 AEST ]]> The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response Tue 16 Oct 2018 12:26:32 AEST ]]> Evaluation of intra- and extra-epithelial secretory IgA in chlamydial infections Tue 16 Oct 2018 11:58:45 AEST ]]> Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens Tue 16 Oct 2018 11:51:23 AEST ]]> The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence Tue 16 Oct 2018 11:51:13 AEST ]]> Development status and future prospects for a vaccine against Chlamydia trachomatis infection Tue 16 Oct 2018 11:51:01 AEST ]]> Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas Tue 16 Oct 2018 11:49:49 AEST ]]> Koala translocations and Chlamydia: Managing risk in the effort to conserve native species Tue 16 Oct 2018 11:41:09 AEST ]]> Type III secretion, contact-dependent model for the intracellular development of Chlamydia Tue 16 Oct 2018 11:30:48 AEST ]]> Proof of concept: A bioinformatic and serological screening method for identifying new peptide antigens for Chlamydia trachomatis related sequelae in women Tue 16 Oct 2018 11:27:55 AEST ]]> Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters Tue 16 Oct 2018 11:27:40 AEST ]]> CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice Tue 16 Oct 2018 11:27:16 AEST ]]> Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: Evaluation of immunity and pathology Tue 16 Oct 2018 11:27:05 AEST ]]> In silico identification and in vivo analysis of a novel T-cell antigen from Chlamydia, NrdB Tue 16 Oct 2018 11:27:00 AEST ]]> A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice Tue 16 Oct 2018 11:26:57 AEST ]]> CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa Tue 16 Oct 2018 11:26:24 AEST ]]> HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually transmitted infection with Chlamydia trachomatis Tue 16 Oct 2018 11:26:16 AEST ]]> The active site residue V266 of chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions Tue 16 Oct 2018 11:26:13 AEST ]]> Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea pig Chlamydia caviae model Tue 16 Oct 2018 11:26:04 AEST ]]> The Duration of Chlamydia muridarum Genital Tract Infection and Associated Chronic Pathological Changes Are Reduced in IL-17 Knockout Mice but Protection Is Not Increased Further by Immunization Tue 16 Oct 2018 11:25:24 AEST ]]> Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis Tue 16 Oct 2018 11:25:20 AEST ]]> Characterization of in vitro chlamydia muridarum persistence and utilization in an in vivo mouse model of chlamydia vaccine Tue 16 Oct 2018 11:24:44 AEST ]]> Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus) Tue 16 Oct 2018 11:24:32 AEST ]]> Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species 99% identity) C. pneumoniae human genomes (AR39, CWL029, J138 and TW183), providing relatively little insight into strain diversity and evolution of this species.Results: We performed individual gene-by-gene comparisons of the recently sequenced C. pneumoniae koala genome and four C. pneumoniae human genomes to identify species-specific genes, and more importantly, to gain an insight into the genetic diversity and evolution of the species. We selected genes dispersed throughout the chromosome, representing genes that were specific to C. pneumoniae, genes with a demonstrated role in chlamydial biology and/or pathogenicity (n = 49), genes encoding nucleotide salvage or amino acid biosynthesis proteins (n = 6), and extrachromosomal elements (9 plasmid and 2 bacteriophage genes).Conclusions: We have identified strain-specific differences and targets for detection of C. pneumoniae isolates from both human and animal origin. Such characterisation is necessary for an improved understanding of disease transmission and intervention.]]> Tue 16 Oct 2018 11:24:29 AEST ]]> Progesterone Activates Multiple Innate Immune Pathways in Chlamydia trachomatis-Infected Endocervical Cells Tue 16 Oct 2018 11:24:24 AEST ]]> Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA 42°C). HtrA levels were detected to increase by western blot and immunofluorescence during Chlamydia heat shock experiments. Confocal laser scanning microscopy revealed a likely periplasmic localisation of HtrA. During penicillin induced persistence of Chlamydia trachomatis, HtrA levels (as a ratio of LPS) were initially less than control acute cultures (20 h post infection) but increased to more than acute cultures at 44 h post infection. This was unlike IFN-γ persistence where lower levels of HtrA were observed, suggesting Chlamydia trachomatis IFN-γ persistence does not involve a broad stress response. Conclusion. The heterologous heat shock protection for Escherichia coli, and increased HtrA during cell wall disruption via penicillin and heat shock, indicates an important role for HtrA during high protein stress conditions for Chlamydia trachomatis.]]> Tue 16 Oct 2018 11:24:12 AEST ]]> Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence Tue 16 Oct 2018 11:24:06 AEST ]]> Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling Tue 16 Oct 2018 11:23:55 AEST ]]> Molecular characterisation and expression analysis of Interferon gamma in response to natural Chlamydia infection in the koala, Phascolarctos cinereus Tue 16 Oct 2018 11:23:48 AEST ]]> "Candidatus Similichlamydia laticola", a novel Chlamydia-like agent of epitheliocystis in seven consecutive cohorts of farmed Australian barramundi, Lates calcarifer (bloch) Thu 17 Nov 2016 11:06:44 AEST ]]> Is disease a major causal factor in declines? An Evidence Framework and case study on koala chlamydiosis Thu 12 Apr 2018 15:18:52 AEST ]]> Detection of a range of genetically diverse chlamydiae in Australian domesticated and wild ungulates Thu 08 Aug 2019 16:49:39 AEST ]]> Koala immunology and infectious diseases: How much can the koala bear? Thu 03 Jan 2019 14:53:10 AEST ]]> A Multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (phascolarctos cinereus): Comparison of three different adjuvants 270 days were also induced in ISC-immunized animals. Chlamydia-specific peripheral blood mononuclear cell proliferative responses were elicited by both Alhydrogel and ISC, and these lasted >270 days in the ISC group. Conclusion: The data show that a multi-subunit chlamydial vaccine, given subcutaneously, can elicit Chlamydia-specific cell-mediated and antibody responses in the koala demonstrating that the development of a protective vaccine is feasible.]]> Fri 30 Aug 2019 13:45:49 AEST ]]> Apoptosis is Induced in Chlamydia trachomatis-infected HEp-2 Cells by the Addition of a Combination Innate Immune Activation Compounds and the Inhibitor Wedelolactone Fri 30 Aug 2019 13:45:44 AEST ]]> Poly-Immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection Fri 30 Aug 2019 13:45:41 AEST ]]> Culture-independent genomics supports pathogen discovery for uncultivable bacteria within the genus Chlamydia Fri 09 Aug 2019 16:09:39 AEST ]]>