Cerebral glucose metabolism on positron emission tomography of children

Zack Y Shan; A J Leiker; A Onar-Thomas; Y Li; T Feng; W E Reddick; D C Reutens; B L Shulkin

doi:10.1002/hbm.22328

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Cerebral glucose metabolism on positron emission tomography of children

Journal article

Peer reviewed

Cerebral glucose metabolism on positron emission tomography of children

Zack Y Shan, A J Leiker, A Onar-Thomas, Y Li, T Feng, W E Reddick, D C Reutens and B L Shulkin

Human Brain Mapping, Vol.35(5), pp.2297-2309

2014

DOI: https://doi.org/10.1002/hbm.22328

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Abstract

child development

brain imaging

glucose metabolism

FDG-PET

SUVs

Establishing the normative range of age-dependent fluorodeoxyglucose (FDG) uptake in the developing brain is necessary for understanding regional quantitative analysis of positron emission tomography (PET) brain images in children and also to provide functional information on brain development. We analyzed head sections of FDG PET/computed tomography (CT) images for 115 patients (5 months to 23 years) without central nervous system disease before treatment, as PET studies are not performed on healthy children owing to ethical considerations and the risk of radiation exposure. We investigated the changes in FDG uptake and established age-associated normative ranges of cerebral FDG. Head sections of FDG PET/CT images were registered to a population-based probabilistic atlas of human cortical structures. Gray matter of 56 brain structures was defined on normalized PET images according to the atlas. To avoid individual and experimental confounding factors, the relative standardized uptake value (SUV) over the cerebellum of each structure was calculated. Relative SUVs were analyzed by ANOVA and modeled using generalized estimating equalization analysis with false discovery rate control. Age and structure were significant factors affecting SUVs. Anatomic proximity had little effect on FDG uptake. Linear and quadratic developmental trajectories were observed on absolute and relative SUVs, respectively. An increase from posterior-to-anterior and superior-to-inferior pattern was observed in both absolute SUV increase rate and relative SUV peak age. The SUV of each structure was modeled with respect to age, and these models can serve as baselines for the quantitative analysis of cerebral FDG-PET images of children.

Details

Title: Cerebral glucose metabolism on positron emission tomography of children
Authors: Zack Y Shan (Author) - University of Queensland
A J Leiker (Author) - Fort Hays State University, United States
A Onar-Thomas (Author) - St. Jude Children's Research Hospital, United States
Y Li (Author) - St. Jude Children's Research Hospital, United States
T Feng (Author) - St. Jude Children's Research Hospital, United States
W E Reddick (Author) - St. Jude Children's Research Hospital, United States
D C Reutens (Author) - University of Queensland
B L Shulkin (Author) - St. Jude Children's Research Hospital, United States
Publication details: Human Brain Mapping, Vol.35(5), pp.2297-2309
Publisher: John Wiley & Sons Inc.
Date published: 2014
DOI: 10.1002/hbm.22328
ISSN: 1065-9471
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451217602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neuroimaging; Neurosciences; Radiology, Nuclear Medicine & Medical Imaging

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