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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Brain function characteristics of chronic fatigue syndrome: A task fMRI study
NeuroImage: Clinical, Vol.19, pp.279-286
2018
Appears in Thompson Institute Research Collection
Abstract
The mechanism underlying neurological dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is yet to be established. This study investigated the temporal complexity of blood oxygenation level dependent (BOLD) changes in response to the Stroop task in CFS patients. 43 CFS patients (47.4±11.8 yrs) and 26 normal controls (NCs, 43.4±13.9 yrs) were included in this study. Their mental component summary (MCS) and physical component summary (PCS) from the 36-item Short Form Health Survey (SF-36) questionnaire were recorded. Their Stroop colour-word task performance was measured by accuracy and response time (RT). The BOLD changes associated with the Stroop task were evaluated using a 2-level general linear model approach. The temporal complexity of the BOLD responses, a measure of information capacity and thus adaptability to a challenging environment, in each activated region was measured by sample entropy (SampEn). The CFS patients showed significantly longer RTs than the NCs (P < 0.05) but no significant difference in accuracy. One sample t-tests for the two groups (Family wise error adjusted PFWE < 0.05) showed more BOLD activation regions in the CFS, although a two sample group comparison did not show significant difference. BOLD SampEns in ten regions were significantly lower (FDR-q < 0.05) in CFS patients. BOLD SampEns in 15 regions were significantly associated with PCS (FDR-q < 0.05) and in 9 regions were associated with MCS (FDR-q < 0.05) across all subjects. SampEn of the BOLD signal in the medioventral occipital cortex could explain 40% and 31% of the variance in the SF-36 PCS and MCS scores, and those in the precentral gyrus could explain an additional 16% and 7% across all subjects. This is the first study to investigate BOLD signal SampEn in response to tasks in CFS. The results suggest the brain responds differently to a cognitive challenge in patients with CFS, with recruitment of wider regions to compensate for lower information capacity.
Details
- Title
- Brain function characteristics of chronic fatigue syndrome: A task fMRI study
- Authors
- Zack Y Shan (Corresponding Author) - Griffith UniversityKevin Finegan (Author) - Gold Coast University HospitalSandeep Bhuta (Author) - Gold Coast University HospitalTimothy Ireland (Author) - Gold Coast University HospitalDonald R Staines (Author) - Griffith UniversitySonya M Marshall-Gradisnik (Author) - Griffith UniversityLeighton R Barnden (Author) - Griffith University
- Publication details
- NeuroImage: Clinical, Vol.19, pp.279-286
- Publisher
- Elsevier BV
- Date published
- 2018
- DOI
- 10.1016/j.nicl.2018.04.025
- ISSN
- 2213-1582; 2213-1582
- Copyright note
- Copyright © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99450775602621
- Output Type
- Journal article
- Research Statement
- false
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