Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

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Title: Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities
Author/Creator: Tran, Trong D | Wilson, Brice A P | Henrich, Curtis J | Staudt, Louis M | Krumpe, Lauren R H | Smith, Emily A | King, Jarrod | Wendt, Karen L | Stchigel, Alberto M | Miller, Andrew N | Cichewicz, Robert H | O'Keefe, Barry R | Gustafson, Kirk R
Description: Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1−6, together with five known compounds, 7− 11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3−6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3−5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.
Relation: Journal of Natural Productions / Vol. 82, No. 1, pp.154-162
Relation: http://dx.doi.org/10.1021/acs.jnatprod.8b00871
Year: 2019
Publisher: American Chemical Society
Subject: FoR 03 (Chemical Sciences) | FoR 06 (Biological Sciences) | FoR 11 (Medical and Health Sciences)

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