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The Secretome and Secretory Capabilities of the Marine Sponge Amphimedon queenslandica
Dissertation   Open access

The Secretome and Secretory Capabilities of the Marine Sponge Amphimedon queenslandica

Michael Hammond
University of the Sunshine Coast, Queensland
Doctor of Philosophy, University of the Sunshine Coast
2017
DOI:
https://doi.org/10.25907/00661
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Abstract

sponge Proteome Ependymin secreted proteins Metazoa multicellularity
Sponges are an ancient group of animals that evolved more than 600 million years ago. They occupy an ecological niche as immobile filter feeders, which has not changed since their establishment. As such, they are thought to be the closest link to the universal metazoan ancestor from which all animals are descended. The study of sponges has the ability to elucidate the commonalities to all multicellular animals, regardless of complexity. The process of cell-cell communication is essential to the maintenance of multicellular bodies and the role that secreted proteins and peptides play in signalling between cells in early metazoa has been left largely unexplored. In this thesis, the demosponge Amphimedon queenslandica was used to determine its peptide secretory capabilities and then commonalities with other members of metazoa.

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