Reliability of oscillometric central hemodynamic responses to an orthostatic challenge

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Reliability of oscillometric central hemodynamic responses to an orthostatic challenge

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Title: Reliability of oscillometric central hemodynamic responses to an orthostatic challenge
Author/Creator: Stoner, L | Bonner, C | Credeur, D | Lambrick, D | Faulkner, J | Wadsworth, Daniel P | Williams, M A
Description: Background: Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can be used to reliably (between-day) assess central blood pressure and central pressure augmentation (augmentation index) responses to a 5 min orthostatic challenge (modified tilt-table). Methods: Twenty healthy adults (26.4 y (SD 5.2), 55% F, 24.7 kg/m2 (SD 3.8)) were tested on 3 different mornings in the fasted state, separated by a maximum of 7 days. Central hemodynamic variables were assessed on the left arm using an oscillometric device. Results: Repeated measures analysis of variance indicated a significant main effect of the modified tilt-table for all central hemodynamic variables (P < 0.001). In response to the tilt, central diastolic pressure increased by 4.5 mmHg (CI: 2.6, 6.4), central systolic blood pressure increased by 2.3 (CI: 4.4, 0.16) mmHg, and augmentation index decreased by an absolute - 5.3%, (CI: -2.7, -7.9%). The intra-class correlation coefficient values for central diastolic pressure (0.83-0.86), central systolic blood pressure (0.80-0.87) and AIx (0.79-0.82) were above the 0.75 criterion in both the supine and tilted positions, indicating excellent between-day reliability. Conclusion: Central hemodynamic responses to an orthostatic challenge can be assessed with acceptable between-day reliability using oscillometric pulse wave analysis. © 2015 Elsevier Ireland Ltd.
Relation: Atherosclerosis / Vol. 241, No. 2, pp.761-765
Relation: http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.041
Year: 2015
Publisher: Elsevier Ireland Ltd.
Subject: FoR 1103 (Clinical Sciences) | FoR 1102 (Cardiorespiratory Medicine and Haematology) | pulse wave analysis | orthostatic challenge | central blood pressure | arterial wave reflection | augmentation index

Resource Type: Journal Article
Identifier: ISSN: 0021-9150
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