Journal article
Diagnostic accuracy of memory measures in Alzheimer’s dementia and Mild Cognitive Impairment: A systematic review and meta-analysis
Neuropsychology Review, Vol.27(4), pp.354-388
2017
Abstract
With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer's dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall. Examination of MCI versus HC studies (n = 38) revealed generally lower diagnostic accuracy for both immediate (sensitivity = 72%, specificity = 81%) and delayed memory (sensitivity = 75%, specificity = 81%). Measures that differentiated AD from other conditions (n = 10 studies) yielded mixed results, with generally high sensitivity in the context of low or variable specificity. Results confirm that memory measures have high diagnostic accuracy for identification of AD, are promising but require further refinement for identification of MCI, and provide support for ongoing investigation of neuropsychological assessment as a cognitive biomarker of preclinical AD. Emphasizing diagnostic test accuracy statistics over null hypothesis testing in future studies will promote the ongoing use of neuropsychological tests as Alzheimer's disease research and clinical criteria increasingly rely upon cerebrospinal fluid (CSF) and neuroimaging biomarkers.
Details
- Title
- Diagnostic accuracy of memory measures in Alzheimer’s dementia and Mild Cognitive Impairment: A systematic review and meta-analysis
- Authors
- Gali H Weissberger (Author) - VA Los Angeles Healthcare System, United StatesJessica V Strong (Author) - VA Boston Healthcare System, United StatesKayla B Stefanidis (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawMathew J Summers (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawM W Bondi (Author) - VA San Diego Healthcare System, United StatesN H Stricker (Author) - VA Boston Healthcare System, United States
- Publication details
- Neuropsychology Review, Vol.27(4), pp.354-388
- Publisher
- Springer New York LLC
- Date published
- 2017
- DOI
- 10.1007/s11065-017-9360-6
- ISSN
- 1040-7308
- Copyright note
- Copyright © 2017 Springer New York LLC. The author's accepted version is reproduced here in accordance with the publisher's copyright policy. The final publication is available at Springer via http://dx.doi.org/10.1007/s11065-017-9360-6
- Organisation Unit
- Road Safety Research Collaboration; School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; Thompson Institute; School of Health - Psychology; School of Law and Society; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450345102621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Neurosciences
- Psychology, Clinical
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