Journal article
Significance of population size on the fixation of nonsynonymous mutations in genes under varying levels of selection pressure
Genetics, Vol.193(3), pp.995-1002
2013
Abstract
Previous studies observed a higher ratio of divergences at nonsynonymous and synonymous sites (ω = dN/dS) in species with a small population size compared to that estimated for those with a large population size. Here we examined the theoretical relationship between ω, effective population size (Ne), and selection coefficient (s). Our analysis revealed that when purifying selection is high, v of species with small Ne is much higher than that of species with large Ne. However the difference between the two ω reduces with the decline in selection pressure (s → 0). We examined this relationship using primate and rodent genes and found that the v estimated for highly constrained genes of primates was up to 2.9 times higher than that obtained for their orthologous rodent genes. Conversely, for genes under weak purifying selection the v of primates was only 17% higher than that of rodents. When tissue specificity was used as a proxy for selection pressure we found that the v of broadly expressed genes of primates was up to 2.1-fold higher than that of their rodent counterparts and this difference was only 27% for tissue specific genes. Since most of the nonsynonymous mutations in constrained or broadly expressed genes are deleterious, fixation of these mutations is influenced by Ne. This results in a higher ω of these genes in primates compared to those from rodents. Conversely, the majority of nonsynonymous mutations in less-constrained or tissue-specific genes are neutral or nearly neutral and therefore fixation of them is largely independent of Ne, which leads to the similarity of ω in primates and rodents. © 2013 by the Genetics Society of America.
Details
- Title
- Significance of population size on the fixation of nonsynonymous mutations in genes under varying levels of selection pressure
- Authors
- Sankar Subramanian (Author) - Griffith University
- Publication details
- Genetics, Vol.193(3), pp.995-1002
- Publisher
- Genetics Society of America
- Date published
- 2013
- DOI
- 10.1534/genetics.112.147900
- ISSN
- 0016-6731
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450562202621
- Output Type
- Journal article
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