Seasonal changes in haematology, lymphocyte transferrin receptors and intracellular iron in Ironman triathletes and untrained men

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Seasonal changes in haematology, lymphocyte transferrin receptors and intracellular iron in Ironman triathletes and untrained men

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Title: Seasonal changes in haematology, lymphocyte transferrin receptors and intracellular iron in Ironman triathletes and untrained men
Author/Creator: Broadbent, Suzanne
Description: We investigated whether 12 months of chronic endurance training would affect haematology, CD4 + lymphocyte transferrin receptor (CD71) expression, CD4 + intracellular iron and the incidence of upper respiratory tract illnesses (URTI) in Ironman triathletes compared with untrained men. Resting venous blood samples were taken from 15 Ironman triathletes (TR 30 ± 5 year) and 12 untrained men (UT 30 ± 6 year) every 4 weeks for 12 months. Erythrocyte, leukocyte and platelet concentration, haematocrit, haemoglobin (Hb) and mean corpuscular haemoglobin (MCHC) were measured with a full blood count. CD4 + lymphocytes were analysed for changes in transferrin receptor (CD71) expression (CD4 +CD71 +), and intracellular iron (Fe 3+), by flow cytometry. The TR group had significantly lower Hb, MCHC, and platelets for 10, 9 and 11 months, respectively; lower CD4 +CD71 + (3 months) and Fe 3+ (1 month), respectively; higher CD4 +CD71 + (1 month); a higher lymphocyte count for 4 months. There were no between-group differences in other variables. In both groups haematology and lymphocytes increased during spring, early summer and winter and decreased during late summer/late winter, with an inverse relationship between CD4 +CD71 + and Fe 3+. The TR group reported significantly fewer URTI than the UT. Low Hb and MCHC suggest an iron deficiency which may affect triathlete performance. Monthly changes in lymphocytes, CD4 +CD71 + and Fe 3+ suggested that spring, summer and late autumn are associated with CD4 + proliferation. There may be seasonal relationships between haematology and lymphocyte function, independent of endurance training, possibly affecting performance but not the incidence of URTI. © 2010 Springer-Verlag.
Relation: European Journal of Applied Physiology / Vol. 111, No. 1, pp.93-100
Relation: http://dx.doi.org/10.1007/s00421-010-1635-z
Year: 2011
Publisher: Springer
Subject: FoR 1106 (Human Movement and Sports Science) | seasonal variations | lymphocytes | transferrin receptors | haemoglobin | intracellular iron

Resource Type: Journal Article
Identifier: ISSN: 1439-6319
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