Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

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Title: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Author/Creator: Eeles, R A | Kote-Jarai, Z | Al Olama, A A | Giles, G G | Guy, M | Severi, G | Muir, K | Hopper, J L | Henderson, B E | Haiman, C A | Schleutker, J | Hamdy, F C | Neal, D E | Donovan, J L | Stanford, J L | Ostrander, E A | Ingles, S A | John, E M | Thibodeau, S N | Schaid, D | Park, J Y | Spurdle, A | Clements, J | Dickinson, J L | Maier, C | Vogel, W | Dörk, T | Rebbeck, T R | Cooney, K A | Cannon-Albright, L | Chappuis, P O | Hutter, P | Zeegers, M | Kaneva, R | Zhang, H W | Lu, Y J | Foulkes, W D | English, D R | Leongamornlert, D A | Tymrakiewicz, M | Morrison, J | Ardern-Jones, A T | Hall, A L | O'Brien, L T | Wilkinson, R A | Saunders, E J | Page, E C | Sawyer, E J | Edwards, S M | Dearnaley, D P | Horwich, A | Huddart, R A | Khoo, V S | Parker, C C | Van As, N | Woodhouse, C J | Thompson, A | Christmas, T | Ogden, C | Cooper, C S | Southey, M C | Lophatananon, A | Liu, J F | Kolonel, L N | Le Marchand, L | Wahlfors, T | Tammela, T L | Auvinen, A | Lewis, S J | Cox, A | Fitzgerald, L M | Koopmeiners, J S | Karyadi, D M | Kwon, E M | Stern, M C | Corral, R | Joshi, A D | Shahabi, A | McDonnell, S K | Sellers, T A | Pow-Sang, J | Chambers, S | Aitken, J | Gardiner, R A | Batra, J | Kedda, M A | Lose, Felicity | Polanowski, A | Patterson, B | Serth, J | Meyer, A | Luedeke, M | Stefflova, K | Ray, A M | Lange, E M | Farnham, J | Khan, H | Slavov, C | Mitkova, A | Cao, G | Easton, D F
Description: Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33). © 2009 Nature America, Inc. All rights reserved.
Relation: Nature Genetics / Vol. 41, No. 10, pp.1116-1121
Relation: http://dx.doi.org/10.1038/ng.450
Year: 2009
Publisher: Nature Publishing Group
Subject: FoR 11 (Medical and Health Sciences) | FoR 06 (Biological Sciences)

Resource Type: Journal Article
Identifier: ISSN: 1061-4036
Rights: Copyright © 2009 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from https://www.nature.com/ng/
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