Background: Animal models have been a valuable tool for research into blood products and outcomes of blood transfusions. Small animal models have been applied extensively and large animal models less frequently. This review describes the experience and details the findings from a recent series of in vivo sheep transfusion models. Aims & Method: To discuss: (i) the benefits of sheep as a large animal transfusion model; and (ii) review conclusions from a series of sheep transfusion models. Results & Discussion: Similarities in size, anatomy and physiology of sheep compared to humans have supported the use of sheep to model a wide range of human diseases, enabled continuous physiological monitoring using standard human techniques, and the collection of multiple and serial samples. Conclusion: The findings discussed demonstrate that sheep are effective models of the blood donor, donations and of transfusion recipients. Importantly, they also define limitations of ovine models, which need to be considered when designing in vivo sheep models of transfusion.
26th Regional Congress of the International Society of Blood Transfusion (ISBT), Nusa Dua, Bali 14-16 November 2015
ISBT Science Series / Vol. 11, Supplement 2, pp.73-78