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Published VersionCC BY V4.0, Open Access
Journal article
REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer
Scientific Reports, Vol.6, 23167
2016
Appears in UniSC Supported Open Access Outputs
Abstract
Regeneration is a common phenomenon across multiple animal phyla. Regeneration-related genes (REGs) are critical for fundamental cellular processes such as proliferation and differentiation. Identification of REGs and elucidating their functions may help to further develop effective treatment strategies in regenerative medicine. So far, REGs have been largely identified by small-scale experimental studies and a comprehensive characterization of the diverse biological processes regulated by REGs is lacking. Therefore, there is an ever-growing need to integrate REGs at the genomics, epigenetics, and transcriptome level to provide a reference list of REGs for regeneration and regenerative medicine research. Towards achieving this, we developed the first literature-based database called REGene (REgeneration Gene database). In the current release, REGene contains 948 human (929 protein-coding and 19 non-coding genes) and 8445 homologous genes curated from gene ontology and extensive literature examination. Additionally, the REGene database provides detailed annotations for each REG, including: gene expression, methylation sites, upstream transcription factors, and protein-protein interactions. An analysis of the collected REGs reveals strong links to a variety of cancers in terms of genetic mutation, protein domains, and cellular pathways. We have prepared a web interface to share these regeneration genes, supported by refined browsing and searching functions at http://REGene.bioinfo-minzhao.org/.
Details
- Title
- REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer
- Authors
- Min Zhao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringBronwyn Rotgans (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringTianfang Wang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringScott F Cummins (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Scientific Reports, Vol.6, 23167; 11
- Publisher
- Nature Publishing Group
- Date published
- 2016
- DOI
- 10.1038/srep23167
- ISSN
- 2045-2322; 2045-2322
- Copyright note
- Copyright © 2016 The Author. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- Faculty of Science, Health, Education and Engineering; School of Science and Engineering - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449489702621
- Output Type
- Journal article
- Research Statement
- false
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