Journal article
Proteomic Analysis of the Schistosoma mansoni Miracidium
PLoS One, Vol.11(1), e0147247
2016
Abstract
Despite extensive control efforts, schistosomiasis continues to be a major public health problem in developing nations in the tropics and sub-tropics. The miracidium, along with the cercaria, both of which are water-borne and free-living, are the only two stages in the life-cycle of Schistosoma mansoni which are involved in host invasion. Miracidia penetrate intermediate host snails and develop into sporocysts, which lead to cercariae that can infect humans. Infection of the snail host by the miracidium represents an ideal point at which to interrupt the parasite's life-cycle. This research focuses on an analysis of the miracidium proteome, including those proteins that are secreted. We have identified a repertoire of proteins in the S. mansoni miracidium at 2 hours post-hatch, including proteases, venom allergen-like proteins, receptors and HSP70, which might play roles in snail-parasite interplay. Proteins involved in energy production and conservation were prevalent, as were proteins predicted to be associated with defence. This study also provides a strong foundation for further understanding the roles that neurohormones play in host-seeking by schistosomes, with the potential for development of novel anthelmintics that interfere with its various life-cycle stages.
Details
- Title
- Proteomic Analysis of the Schistosoma mansoni Miracidium
- Authors
- Tianfang Wang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMin Zhao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringBronwyn Rotgans (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringApril Strong (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringDi Liang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringGuoying Ni (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringYanin Limpanont (Author) - Mahidol University, ThailandPongrama Ramasoota (Author) - Mahidol University, ThailandDonald P McManus (Author) - QIMR Berghofer Medical Research InstituteScott F Cummins (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- PLoS One, Vol.11(1), e0147247; 22
- Publisher
- Public Library of Science
- Date published
- 2016
- DOI
- 10.1371/journal.pone.0147247
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2016 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- Faculty of Science, Health, Education and Engineering; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450201802621
- Output Type
- Journal article
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