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Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer

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- Title
- Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer
- Author/Creator
-
Walker, G J |
Kimlin, Michael G |
Hacker, E |
Ravishankar, S |
Muller, H K |
Beermann, F |
Hayward, N K
- Description
- Melanocytes respond to UVR not only by producing melanin, but also by proliferating. This is essentially a protective response. We have studied the melanocyte proliferative response after a single UVR exposure to neonatal mice. At 3 days post-UVR in wild-type neonates we observed a marked melanocyte activation not seen in adults. Melanocytes migrated to the epidermal basal layer, their numbers peaking at 3-5 days after UVR then diminishing. They appeared to emanate from the hair follicle, migrating to the epidermis via the outer root sheath. In melanoma-prone mice with melanocyte-specific overexpression of Hras(G12V), basal layer melanocytes were increased in size and dendricity compared to UVR-treated wild-type mice. Melanocytes in mice carrying a pRb pathway cell-cycle defect (oncogenic Cdk4(R24C)) did not show an enhanced response to UVR such as those carrying Hras(G12V). The exquisite sensitivity to UVR-induced proliferation and migration that characterizes neonatal mouse melanocytes may partly explain the utility of this form of exposure for inducing melanoma in mice that carry oncogenic mutations.
- Relation
- Journal of Investigative Dermatology / Vol. 129, No. 1, pp.184-193
- Relation
- http://dx.doi.org/10.1038/jid.2008.210
- Year
- 2009
- Publisher
- Nature Publishing Group
- Subject
-
FoR 1103 (Clinical Sciences) |
FoR 1112 (Oncology and Carcinogenesis) |
cell proliferation |
epidermis |
melanoma |
radiation exposure |
ultraviolet radiation
- Resource Type
- Journal Article
- Identifier
- ISSN: 0022-202X
- Reviewed

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